Sporadic colorectal cancer: Microbial contributors to disease prevention, development and therapy

Research output: Contribution to journalReview articlepeer-review

Abstract

The gut microbiota has been hailed as an accessory organ, with functions critical to the host including dietary metabolic activities and assistance in the development of a proper functioning immune system. However, an aberrant microbiota (dysbiosis) may influence disease processes such as colorectal cancer. In this review, we discuss recent advances in our understanding of the contributions of the microbiota to prevention, initiation/progression, and treatment of colorectal cancer, with a major focus on biofilms and the antimicrobial and antitumoural immune response.

Original languageEnglish (US)
Pages (from-to)273-280
Number of pages8
JournalBritish journal of cancer
Volume115
Issue number3
DOIs
StatePublished - Jul 26 2016

Keywords

  • biofilms
  • colorectal cancer
  • inflammasomes
  • inflammation
  • microbiota
  • pattern recognition receptors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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