Spontaneous unilateral brainstem infarction in Swiss mice

Teresa Southard, Cory Brayton

Research output: Contribution to journalArticle

Abstract

Spontaneous vestibular syndrome in mice, characterized clinically by head tilt, circling or rolling, can be caused by otitis media, arteritis or central nervous system lesions. Postmortem examination of eleven non-inbred Swiss mice submitted for necropsy due to acute onset of vestibular signs revealed lesions consistent with brainstem infarction. The lesions were characterized by unilateral, well-demarcated areas of necrosis, malacia, and gliosis, with variable amounts of hemorrhage, in the lateral aspect of the medulla and caudal pons. The affected area included the medial, lateral and superior vestibular nuclei, the facial nucleus and the spinal trigeminal nucleus. While vestibular disease secondary to otitis media, periarteritis, and central nervous system neoplasia has been reported in many mouse strains, these unilateral brainstem infarctions were only seen in Swiss mice. These lesions share features with Wallenberg's Lateral Medullary Syndrome, the most common type of brainstem infarct in humans.

Original languageEnglish (US)
Pages (from-to)726-729
Number of pages4
JournalVeterinary Pathology
Volume48
Issue number3
DOIs
StatePublished - May 2011

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Brain Stem Infarctions
infarction
brain stem
lesions (animal)
otitis media
mice
Otitis Media
central nervous system
necropsy
Vestibular Diseases
Lateral Medullary Syndrome
Central Nervous System
Lateral Vestibular Nucleus
Spinal Trigeminal Nucleus
arteritis
Arteritis
Gliosis
Pons
Brain Stem
hemorrhage

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Spontaneous unilateral brainstem infarction in Swiss mice. / Southard, Teresa; Brayton, Cory.

In: Veterinary Pathology, Vol. 48, No. 3, 05.2011, p. 726-729.

Research output: Contribution to journalArticle

Southard, Teresa ; Brayton, Cory. / Spontaneous unilateral brainstem infarction in Swiss mice. In: Veterinary Pathology. 2011 ; Vol. 48, No. 3. pp. 726-729.
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