Spontaneous remodeling of the peripheral retinal vasculature in sickling disorders

Spiros O. Galinos, George K. Asdourian, Michael B. Woolf, Thomas S. Stevens, Chang Bok Lee, Morton F. Goldberg, Joseph C.F. Chow, Bruce J. Busse

Research output: Contribution to journalArticle

Abstract

Periodic photographic and angiographic surveys of patients with the earliest stages of sickle retinopathy showed a number of fundus findings. In seven cases (sickle cell anemia, four; sickle cell hemoglobin C, three), these findings included: (1) a variety of vascular abnormalities in the equatorial and post-equatorial retina such as segmented dilations of the vessel walls, hairpin-shaped vascular loops, hypertrophic, tortuous A-V anastomoses, intraluminal plugs, closure and loss of capillary bed, and terminal budding of capillaries; and (2) a continuous, spontaneous remodeling of the peripheral retinal vasculature due to successive closures and reopenings of equatorial retinal vessels. A centripetal recession of the peripheral retinal vasculature usually resulted. No correlation between the ophthalmoscopic and the systemic condition of the patients could be made.

Original languageEnglish (US)
Pages (from-to)853-870
Number of pages18
JournalAmerican journal of ophthalmology
Volume79
Issue number5
DOIs
StatePublished - May 1975
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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    Galinos, S. O., Asdourian, G. K., Woolf, M. B., Stevens, T. S., Lee, C. B., Goldberg, M. F., Chow, J. C. F., & Busse, B. J. (1975). Spontaneous remodeling of the peripheral retinal vasculature in sickling disorders. American journal of ophthalmology, 79(5), 853-870. https://doi.org/10.1016/0002-9394(75)90747-3