Spontaneous regression of multiple intracranial capillary hemangiomas in a newborn—long-term follow-up and literature review

Mohammad Hassan A. Noureldine, Saleh Rasras, Hosein Safari, Mohammadmahdi Sabahi, George I. Jallo, Mahdi Arjipour

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Intracranial capillary hemangiomas (ICHs) have a natural history and behavior that is very different from intracranial cavernous malformations. The literature is not consistent as to the best management strategy for ICHs. Case description: Our patient is a 40-day-old male infant who presented with progressive increase in head circumference and multiple cutaneous capillary and ICHs. Obstructive hydrocephalus necessitated urgent cerebrospinal fluid (CSF) diversion, but no other surgical intervention was pursued due to the high risk-to-benefit ratio. All intracranial lesions spontaneously regressed by 11 years of age, albeit at a slower speed than the cutaneous lesions, with no functional or cognitive sequelae. We conducted a comprehensive literature review and provided a summary of all reported ICH cases. Conclusion: Asymptomatic patients with ICHs are best approached with close follow-up and serial imaging studies as the potential for spontaneous regression is relatively high. Patients with isolated lesions or unclear diagnoses may benefit from a stereotactic biopsy, and surgical resection should be reserved for symptomatic lesions only.

Original languageEnglish (US)
JournalChild's Nervous System
DOIs
StateAccepted/In press - 2021

Keywords

  • Capillary hemangioma
  • Infantile hemangioma
  • Intracranial
  • Spontaneous regression

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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