Spontaneous benign prostatic hyperplasia in the beagle. Age-associated changes in serum hormone levels, and the morphology and secretory function of the canine prostate

C. B. Brendler, S. J. Berry, L. L. Ewing, A. R. McCullough, R. C. Cochran, J. D. Strandberg, Barry R Zirkin, D. S. Coffey, L. G. Wheaton, M. L. Hiler, M. J. Bordy, G. D. Niswender, W. W. Scott, Patrick Walsh

Research output: Contribution to journalArticle

Abstract

This paper is a cross-sectional study of spontaneous benign prostatic hyperplasia (BPH) in a single canine species. The effects of aging and hormonal changes on the growth, histology, and glandular secretory function of the canine prostate were studied in 42 male beagles ranging in age from 8 mo to 9 yr. The beagle prostate enlarges for at least 6 yr, whether normal or hyperplastic. In contrast, prostatic secretory function, determined by ejaculate volume and total ejaculate protein, declines markedly after 4 yr of age. These reciprocal growth and functional changes in the prostate are closely associated with a progressive increase in the incidence of BPH, which is already apparent in some dogs by age two. With age there is a modest decrease in serum androgen levels with no apparent change in serum 17β-estradiol levels. This suggests that the growth and functional changes that are associated with the development of BPH and are initiated very early in life reflect an altered sensitivity of the prostate to serum androgens or a response to the relative decrease in the serum androgen to estrogen ratio.

Original languageEnglish (US)
Pages (from-to)1114-1123
Number of pages10
JournalJournal of Clinical Investigation
Volume71
Issue number5
StatePublished - 1983
Externally publishedYes

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Prostatic Hyperplasia
Canidae
Prostate
Hormones
Androgens
Serum
Growth
Estradiol
Histology
Estrogens
Cross-Sectional Studies
Dogs
Incidence
Proteins

ASJC Scopus subject areas

  • Medicine(all)

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Spontaneous benign prostatic hyperplasia in the beagle. Age-associated changes in serum hormone levels, and the morphology and secretory function of the canine prostate. / Brendler, C. B.; Berry, S. J.; Ewing, L. L.; McCullough, A. R.; Cochran, R. C.; Strandberg, J. D.; Zirkin, Barry R; Coffey, D. S.; Wheaton, L. G.; Hiler, M. L.; Bordy, M. J.; Niswender, G. D.; Scott, W. W.; Walsh, Patrick.

In: Journal of Clinical Investigation, Vol. 71, No. 5, 1983, p. 1114-1123.

Research output: Contribution to journalArticle

Brendler, CB, Berry, SJ, Ewing, LL, McCullough, AR, Cochran, RC, Strandberg, JD, Zirkin, BR, Coffey, DS, Wheaton, LG, Hiler, ML, Bordy, MJ, Niswender, GD, Scott, WW & Walsh, P 1983, 'Spontaneous benign prostatic hyperplasia in the beagle. Age-associated changes in serum hormone levels, and the morphology and secretory function of the canine prostate', Journal of Clinical Investigation, vol. 71, no. 5, pp. 1114-1123.
Brendler, C. B. ; Berry, S. J. ; Ewing, L. L. ; McCullough, A. R. ; Cochran, R. C. ; Strandberg, J. D. ; Zirkin, Barry R ; Coffey, D. S. ; Wheaton, L. G. ; Hiler, M. L. ; Bordy, M. J. ; Niswender, G. D. ; Scott, W. W. ; Walsh, Patrick. / Spontaneous benign prostatic hyperplasia in the beagle. Age-associated changes in serum hormone levels, and the morphology and secretory function of the canine prostate. In: Journal of Clinical Investigation. 1983 ; Vol. 71, No. 5. pp. 1114-1123.
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