Spontaneous autoimmune thyroiditis in the BUF rat.

N. R. Rose, P. E. Bigazzi, B. Noble

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


The inbred BUF rat develops autoimmune thyroiditis spontaneously. The incidence is related to the age of the animal and is increased by neonatal thymectomy and by treatment with methylcholanthrene. Autoantibodies to thyroglobulin can be demonstrated by indirect immunofluorescence and hemagglutination, but skin tests are negative. The "spontaneous" autoimmune disease may be due to the conjunction of an unusually vigorous immunological response to thyroglobulin and the loss of thymic suppressor function.

Original languageEnglish (US)
Pages (from-to)209-216
Number of pages8
JournalAdvances in experimental medicine and biology
Volume73 Pt B
StatePublished - 1976

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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