The immunization of Buffalo strain (BUF) rats with rat thyroid extract and Bordetella pertussis vaccine without complete Freund's adjuvant resulted in experimental autoimmune thyroiditis (EAT) in 90% of the rats by the 10th day after immunization. The treatment did not elicit thyroiditis in Lewis strain (LEW) rats. This susceptibility to the induction of EAT without the use of complete Freund's adjuvant was inherited by F1 hybrids of BUF and LEW. Neither histamine sensitizing factor from B. pertussis nor Escherichia coli vaccine could substitute for whole pertussis vaccine.
|Original language||English (US)|
|Journal||Journal of Immunology|
|State||Published - Jan 1 1975|
ASJC Scopus subject areas
- Immunology and Allergy