Spontaneous and methylcholanthrene enhanced thyroiditis in BUF rats. II. Induction of experimental autoimmune thyroiditis without complete Freund's adjuvant

D. A. Silverman; N. R. Rose

Spontaneous and methylcholanthrene enhanced thyroiditis in BUF rats. II. Induction of experimental autoimmune thyroiditis without complete Freund's adjuvant

D. A. Silverman, N. R. Rose

School of Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The immunization of Buffalo strain (BUF) rats with rat thyroid extract and Bordetella pertussis vaccine without complete Freund's adjuvant resulted in experimental autoimmune thyroiditis (EAT) in 90% of the rats by the 10th day after immunization. The treatment did not elicit thyroiditis in Lewis strain (LEW) rats. This susceptibility to the induction of EAT without the use of complete Freund's adjuvant was inherited by F₁ hybrids of BUF and LEW. Neither histamine sensitizing factor from B. pertussis nor Escherichia coli vaccine could substitute for whole pertussis vaccine.

Original language	English (US)
Pages (from-to)	I
Journal	Journal of Immunology
Volume	114
Issue number	1
State	Published - Jan 1 1975

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Cite this

@article{b74ef34bb0c04c60b1b7e3df6272ece2,

title = "Spontaneous and methylcholanthrene enhanced thyroiditis in BUF rats. II. Induction of experimental autoimmune thyroiditis without complete Freund's adjuvant",

abstract = "The immunization of Buffalo strain (BUF) rats with rat thyroid extract and Bordetella pertussis vaccine without complete Freund's adjuvant resulted in experimental autoimmune thyroiditis (EAT) in 90% of the rats by the 10th day after immunization. The treatment did not elicit thyroiditis in Lewis strain (LEW) rats. This susceptibility to the induction of EAT without the use of complete Freund's adjuvant was inherited by F1 hybrids of BUF and LEW. Neither histamine sensitizing factor from B. pertussis nor Escherichia coli vaccine could substitute for whole pertussis vaccine.",

author = "Silverman, {D. A.} and Rose, {N. R.}",

year = "1975",

month = jan,

day = "1",

language = "English (US)",

volume = "114",

pages = "I",

journal = "Journal of Immunology",

issn = "0022-1767",

publisher = "American Association of Immunologists",

number = "1",

}

TY - JOUR

T1 - Spontaneous and methylcholanthrene enhanced thyroiditis in BUF rats. II. Induction of experimental autoimmune thyroiditis without complete Freund's adjuvant

AU - Silverman, D. A.

AU - Rose, N. R.

PY - 1975/1/1

Y1 - 1975/1/1

N2 - The immunization of Buffalo strain (BUF) rats with rat thyroid extract and Bordetella pertussis vaccine without complete Freund's adjuvant resulted in experimental autoimmune thyroiditis (EAT) in 90% of the rats by the 10th day after immunization. The treatment did not elicit thyroiditis in Lewis strain (LEW) rats. This susceptibility to the induction of EAT without the use of complete Freund's adjuvant was inherited by F1 hybrids of BUF and LEW. Neither histamine sensitizing factor from B. pertussis nor Escherichia coli vaccine could substitute for whole pertussis vaccine.

AB - The immunization of Buffalo strain (BUF) rats with rat thyroid extract and Bordetella pertussis vaccine without complete Freund's adjuvant resulted in experimental autoimmune thyroiditis (EAT) in 90% of the rats by the 10th day after immunization. The treatment did not elicit thyroiditis in Lewis strain (LEW) rats. This susceptibility to the induction of EAT without the use of complete Freund's adjuvant was inherited by F1 hybrids of BUF and LEW. Neither histamine sensitizing factor from B. pertussis nor Escherichia coli vaccine could substitute for whole pertussis vaccine.

UR - http://www.scopus.com/inward/record.url?scp=0016425467&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016425467&partnerID=8YFLogxK

M3 - Article

C2 - 46238

AN - SCOPUS:0016425467

SN - 0022-1767

VL - 114

SP - I

JO - Journal of Immunology

JF - Journal of Immunology

IS - 1

ER -

Spontaneous and methylcholanthrene enhanced thyroiditis in BUF rats. II. Induction of experimental autoimmune thyroiditis without complete Freund's adjuvant

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this