Spontaneous and methylcholanthrene enhanced thyroiditis in BUF rats. II. Induction of experimental autoimmune thyroiditis without complete Freund's adjuvant

D. A. Silverman, N. R. Rose

Research output: Contribution to journalArticle

Abstract

The immunization of Buffalo strain (BUF) rats with rat thyroid extract and Bordetella pertussis vaccine without complete Freund's adjuvant resulted in experimental autoimmune thyroiditis (EAT) in 90% of the rats by the 10th day after immunization. The treatment did not elicit thyroiditis in Lewis strain (LEW) rats. This susceptibility to the induction of EAT without the use of complete Freund's adjuvant was inherited by F1 hybrids of BUF and LEW. Neither histamine sensitizing factor from B. pertussis nor Escherichia coli vaccine could substitute for whole pertussis vaccine.

Original languageEnglish (US)
Pages (from-to)I
JournalJournal of Immunology
Volume114
Issue number1
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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