Spongiform polioencephalomyelopathy caused by a murine retrovirus. I. Pathogenesis of infection in newborn mice

B. R. Brooks, J. R. Swarz, R. T. Johnson

Research output: Contribution to journalArticlepeer-review

Abstract

Spongiform polioencephalomyelopathy was produced in Swiss mice by intracerebral or intraperitoneal inoculation of cloned murine neurotropic retrovirus. The incubation period of the paralytic disease and the spongiform degeneration was inversely related to the concentration of the virus inoculum. Clinical signs and pathologic changes were directly related to virus content of the brain and spinal cord regardless of the incubation period. Initial virus replication in the spleen and viremia preceded central nervous system virus replication following either intracerebral or intraperitoneal inoculation. Virus replication was restricted in nonsusceptible BALB/c mice and in susceptible mice made asplenic with cyclophosphamide. The spongiform changes evolved after the peak central nervous system concentration of virus was achieved. Vacuolation in the neuropil preceded vacuolation of neuronal perikaryon by 1 week and neuronal loss by 2 to 4 weeks. The histology of the neurotropic retrovirus-induced spongiform degeneration resembled the subacute spongiform encephalopathies of man and animals.

Original languageEnglish (US)
Pages (from-to)480-486
Number of pages7
JournalLaboratory Investigation
Volume43
Issue number5
StatePublished - 1980

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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