TY - JOUR
T1 - Split operator method for fluorescence diffuse optical tomography using anisotropic diffusion regularisation with prior anatomical information
AU - Correia, Teresa
AU - Aguirre, Juan
AU - Sisniega, Alejandro
AU - Chamorro-Servent, Judit
AU - Abascal, Juan
AU - Vaquero, Juan J.
AU - Desco, Manuel
AU - Kolehmainen, Ville
AU - Arridge, Simon
PY - 2011/9/1
Y1 - 2011/9/1
N2 - Fluorescence diffuse optical tomography (fDOT) is an imaging modality that provides images of the fluorochrome distribution within the object of study. The image reconstruction problem is ill-posed and highly underdetermined and, therefore, regularisation techniques need to be used. In this paper we use a nonlinear anisotropic diffusion regularisation term that incorporates anatomical prior information. We introduce a split operator method that reduces the nonlinear inverse problem to two simpler problems, allowing fast and efficient solution of the fDOT problem. We tested our method using simulated, phantom and ex-vivo mouse data, and found that it provides reconstructions with better spatial localisation and size of fluorochrome inclusions than using the standard Tikhonov penalty term.
AB - Fluorescence diffuse optical tomography (fDOT) is an imaging modality that provides images of the fluorochrome distribution within the object of study. The image reconstruction problem is ill-posed and highly underdetermined and, therefore, regularisation techniques need to be used. In this paper we use a nonlinear anisotropic diffusion regularisation term that incorporates anatomical prior information. We introduce a split operator method that reduces the nonlinear inverse problem to two simpler problems, allowing fast and efficient solution of the fDOT problem. We tested our method using simulated, phantom and ex-vivo mouse data, and found that it provides reconstructions with better spatial localisation and size of fluorochrome inclusions than using the standard Tikhonov penalty term.
UR - http://www.scopus.com/inward/record.url?scp=80855145750&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80855145750&partnerID=8YFLogxK
U2 - 10.1364/BOE.2.002632
DO - 10.1364/BOE.2.002632
M3 - Article
C2 - 22091447
AN - SCOPUS:80855145750
SN - 2156-7085
VL - 2
SP - 2632
EP - 2648
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 9
ER -