Splicing factors are differentially expressed in tumors

Natanja Kirschbaum-Slager, Graziela M P Lopes, Pedro A F Galante, Gregory J Riggins, Sandro J. De Souza

Research output: Contribution to journalArticle

Abstract

Although alternative splicing of many genes has been found associated with different stages of tumorigenesis and splicing variants have been characterized as tumor markers, it is still not known whether these examples are sporadic or whether there is a broader association between the two phenomena. In this report we evaluated, through a bioinformatics approach, the expression of splicing factors in both normal and tumor tissues. This was possible by integrating data produced by proteomics, serial analysis of gene expression (SAGE) and microarray experiments. We observed a significant shift in the expression of splicing factors in tumors in both SAGE and microarray data, resulting from a large amount of experiments. We discuss that this supports the notion of a broader association between alternative splicing and cell transformation, and that splicing factors may be involved in oncogenic pathways.

Original languageEnglish (US)
Pages (from-to)512-520
Number of pages9
JournalGenetics and Molecular Research
Volume3
Issue number4
Publication statusPublished - 2004

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Keywords

  • Alternative splicing
  • SAGE
  • Tumorigenesis

ASJC Scopus subject areas

  • Genetics

Cite this

Kirschbaum-Slager, N., Lopes, G. M. P., Galante, P. A. F., Riggins, G. J., & De Souza, S. J. (2004). Splicing factors are differentially expressed in tumors. Genetics and Molecular Research, 3(4), 512-520.