TY - JOUR
T1 - Splicing factors are differentially expressed in tumors
AU - Kirschbaum-Slager, Natanja
AU - Lopes, Graziela M.P.
AU - Galante, Pedro A.F.
AU - Riggins, Gregory J.
AU - De Souza, Sandro J.
PY - 2004/12/1
Y1 - 2004/12/1
N2 - Although alternative splicing of many genes has been found associated with different stages of tumorigenesis and splicing variants have been characterized as tumor markers, it is still not known whether these examples are sporadic or whether there is a broader association between the two phenomena. In this report we evaluated, through a bioinformatics approach, the expression of splicing factors in both normal and tumor tissues. This was possible by integrating data produced by proteomics, serial analysis of gene expression (SAGE) and microarray experiments. We observed a significant shift in the expression of splicing factors in tumors in both SAGE and microarray data, resulting from a large amount of experiments. We discuss that this supports the notion of a broader association between alternative splicing and cell transformation, and that splicing factors may be involved in oncogenic pathways.
AB - Although alternative splicing of many genes has been found associated with different stages of tumorigenesis and splicing variants have been characterized as tumor markers, it is still not known whether these examples are sporadic or whether there is a broader association between the two phenomena. In this report we evaluated, through a bioinformatics approach, the expression of splicing factors in both normal and tumor tissues. This was possible by integrating data produced by proteomics, serial analysis of gene expression (SAGE) and microarray experiments. We observed a significant shift in the expression of splicing factors in tumors in both SAGE and microarray data, resulting from a large amount of experiments. We discuss that this supports the notion of a broader association between alternative splicing and cell transformation, and that splicing factors may be involved in oncogenic pathways.
KW - Alternative splicing
KW - SAGE
KW - Tumorigenesis
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M3 - Article
C2 - 15688317
AN - SCOPUS:14644437799
SN - 1676-5680
VL - 3
SP - 512
EP - 520
JO - Genetics and Molecular Research
JF - Genetics and Molecular Research
IS - 4
ER -