Splicing and Dicing MYC-Mediated Synthetic Lethality

Zachary E. Stine, Chi V. Dang

Research output: Contribution to journalArticle

Abstract

In a recent issue of Nature, Hsu and colleagues report that oncogenic MYC activation is synthetic lethal with inhibition of the core spliceosome, because MYC-driven growth and increased transcription leave tumors dependent on pre-mRNA processing for survival. As direct targeting of MYC has remained elusive, synthetic lethal strategies are attractive.

Original languageEnglish (US)
Article number2152
Pages (from-to)405-406
Number of pages2
JournalCancer Cell
Volume28
Issue number4
DOIs
StatePublished - Oct 12 2015
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology
  • Medicine(all)

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