Splenic injury caused by therapeutic irradiation

M. O. Dailey, C. N. Coleman, L. F. Fajardo

Research output: Contribution to journalArticle

Abstract

Splenic irradiation in the course of therapy for lymphoma can result in functional deficit, sometimes as severe as that caused by splenectomy, placing the patient at risk for fatal infection. We examined 33 spleens obtained at necropsy from patients irradiated for lymphomas (mainly Hodgkin's disease) and compared them with 18 non irradiated spleens from similar patients. One to 8 years after a mean radiation dose of 3899 rads, fractionated over 5-6 weeks, most irradiated spleens were small (average weight 75 g) and had thick, wrinkled capsules, often with focal hemorrhage. There was collapse of the parenchyma, with close apposition of trabeculae and mild to severe diffuse fibrosis of the red pulp. Lymphocyte depletion was obvious in more than 50% of the specimens. The most consistent alteration was myointimal proliferation of arteries. Significant intimal thickening was seen only in the irradiated specimens. Similar myointimal changes were found in the veins of three cases. While none of these changes is specific, their combination appears to be characteristic of delayed radiation injury to the spleen.

Original languageEnglish (US)
Pages (from-to)325-331
Number of pages7
JournalAmerican Journal of Surgical Pathology
Volume5
Issue number4
StatePublished - 1981
Externally publishedYes

Fingerprint

Spleen
Wounds and Injuries
Lymphoma
Tunica Intima
Lymphocyte Depletion
Radiation Injuries
Splenectomy
Therapeutics
Hodgkin Disease
Capsules
Veins
Fibrosis
Arteries
Radiation
Hemorrhage
Weights and Measures
Infection

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Dailey, M. O., Coleman, C. N., & Fajardo, L. F. (1981). Splenic injury caused by therapeutic irradiation. American Journal of Surgical Pathology, 5(4), 325-331.

Splenic injury caused by therapeutic irradiation. / Dailey, M. O.; Coleman, C. N.; Fajardo, L. F.

In: American Journal of Surgical Pathology, Vol. 5, No. 4, 1981, p. 325-331.

Research output: Contribution to journalArticle

Dailey, MO, Coleman, CN & Fajardo, LF 1981, 'Splenic injury caused by therapeutic irradiation', American Journal of Surgical Pathology, vol. 5, no. 4, pp. 325-331.
Dailey, M. O. ; Coleman, C. N. ; Fajardo, L. F. / Splenic injury caused by therapeutic irradiation. In: American Journal of Surgical Pathology. 1981 ; Vol. 5, No. 4. pp. 325-331.
@article{24236f6018f043df9da374e850d798df,
title = "Splenic injury caused by therapeutic irradiation",
abstract = "Splenic irradiation in the course of therapy for lymphoma can result in functional deficit, sometimes as severe as that caused by splenectomy, placing the patient at risk for fatal infection. We examined 33 spleens obtained at necropsy from patients irradiated for lymphomas (mainly Hodgkin's disease) and compared them with 18 non irradiated spleens from similar patients. One to 8 years after a mean radiation dose of 3899 rads, fractionated over 5-6 weeks, most irradiated spleens were small (average weight 75 g) and had thick, wrinkled capsules, often with focal hemorrhage. There was collapse of the parenchyma, with close apposition of trabeculae and mild to severe diffuse fibrosis of the red pulp. Lymphocyte depletion was obvious in more than 50{\%} of the specimens. The most consistent alteration was myointimal proliferation of arteries. Significant intimal thickening was seen only in the irradiated specimens. Similar myointimal changes were found in the veins of three cases. While none of these changes is specific, their combination appears to be characteristic of delayed radiation injury to the spleen.",
author = "Dailey, {M. O.} and Coleman, {C. N.} and Fajardo, {L. F.}",
year = "1981",
language = "English (US)",
volume = "5",
pages = "325--331",
journal = "American Journal of Surgical Pathology",
issn = "0147-5185",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Splenic injury caused by therapeutic irradiation

AU - Dailey, M. O.

AU - Coleman, C. N.

AU - Fajardo, L. F.

PY - 1981

Y1 - 1981

N2 - Splenic irradiation in the course of therapy for lymphoma can result in functional deficit, sometimes as severe as that caused by splenectomy, placing the patient at risk for fatal infection. We examined 33 spleens obtained at necropsy from patients irradiated for lymphomas (mainly Hodgkin's disease) and compared them with 18 non irradiated spleens from similar patients. One to 8 years after a mean radiation dose of 3899 rads, fractionated over 5-6 weeks, most irradiated spleens were small (average weight 75 g) and had thick, wrinkled capsules, often with focal hemorrhage. There was collapse of the parenchyma, with close apposition of trabeculae and mild to severe diffuse fibrosis of the red pulp. Lymphocyte depletion was obvious in more than 50% of the specimens. The most consistent alteration was myointimal proliferation of arteries. Significant intimal thickening was seen only in the irradiated specimens. Similar myointimal changes were found in the veins of three cases. While none of these changes is specific, their combination appears to be characteristic of delayed radiation injury to the spleen.

AB - Splenic irradiation in the course of therapy for lymphoma can result in functional deficit, sometimes as severe as that caused by splenectomy, placing the patient at risk for fatal infection. We examined 33 spleens obtained at necropsy from patients irradiated for lymphomas (mainly Hodgkin's disease) and compared them with 18 non irradiated spleens from similar patients. One to 8 years after a mean radiation dose of 3899 rads, fractionated over 5-6 weeks, most irradiated spleens were small (average weight 75 g) and had thick, wrinkled capsules, often with focal hemorrhage. There was collapse of the parenchyma, with close apposition of trabeculae and mild to severe diffuse fibrosis of the red pulp. Lymphocyte depletion was obvious in more than 50% of the specimens. The most consistent alteration was myointimal proliferation of arteries. Significant intimal thickening was seen only in the irradiated specimens. Similar myointimal changes were found in the veins of three cases. While none of these changes is specific, their combination appears to be characteristic of delayed radiation injury to the spleen.

UR - http://www.scopus.com/inward/record.url?scp=0019412669&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019412669&partnerID=8YFLogxK

M3 - Article

C2 - 7270781

AN - SCOPUS:0019412669

VL - 5

SP - 325

EP - 331

JO - American Journal of Surgical Pathology

JF - American Journal of Surgical Pathology

SN - 0147-5185

IS - 4

ER -