TY - JOUR
T1 - Splenic fibrosis and sarcomas in f344 rats fed diets containing aniline hydrochloride, p-chloroaniline, azobenzene, o-toluidine hydrochloride, 4, 4′-sulfonyldianiline, or d & c red no. 9
AU - Goodman, D. G.
AU - Ward, J. M.
AU - Reichardt, W. D.
N1 - Funding Information:
1 Received November 14, 1983; accepted March 2, 1984. 2 Supported in part by Public Health Service contract NOICP-95646 from the National Toxicology Program and the Division of Cancer Cause and Prevention, National Cancer Institute. 3 Clement Associates. Inc.. 1515 Wilson Blvd .. Arlington, Va. 22209. 4 Tumor Pathology and Pathogenesis Section, Laboratory of Com· parative Carcinogenesis. Division of Cancer Etiology. National Cancer Institute, National Institutes of Health. Public Health Service, U.S. Department of Health and Human Services. NCI-Frederick Cancer Research Facility, Frederick, Md. 21701. 'Address reprint requests to Dr. Ward at the NCI-Frederick Cancer Research Facility, Building 538. Room 205A. Frederick. Md. 21701. 6 We are grateful for the successful implementation of these studies by the Principal Investigators and Pathologists at the contract laboratories acknowledged in the National Cancer Institute or National Toxicology Program technical reports. We thank Mr. Larry Ostby for photomicrography. 7 D & C red No. 9 [CAS: D85500000; 5·chloro-2-((2-hydroxy·l· naphthalenyl)azo)-4-methylbenzenesulfonic acid. barium salt]; azobenzene (CAS: 103·33-3); a·toluidine HCI (CAS: 636-21-5); p·chloro· aniline (CAS: 106-47-8); aniline HCI (CAS: 142·04-1; hydrochloride benzenamide); dapsone (CAS: 80-08·0; 4-4'-sulfonyldianiline).
PY - 1984/7
Y1 - 1984/7
N2 - In six carcinogenicity bioassays, male and female F344 rats were fed diets containing aniline hydrochloride (CAS: 142-04-1; hydrochloride benzenamide), p-chloroaniline (CAS: 106-47-8), azobenzene (CAS: 103-33-3), o-toluidine hydrochloride (CAS: 636-21-5), dapsone (CAS: 80-08-0; 4, 4′-sulfonyldianiline), or D & C red No. 9 [CAS: D85500000; 5-chloro-2-((2-hydroxy-1-naphthalenyl)azo)-4-methylbenzenesulfonic acid, barium salt]. The rats, from 6 weeks to 2 years old, were given the compounds at two dose levels, the estimated maximum tolerated dose and one-half that dose. In all six bioassays, dose-dependent incidences of splenic sarcomas and fibrosis were seen, with the highest incidences in male rats. Fibrosis occurred in the splenic parenchyma and/or the capsule. Fatty infiltration also was seen in the spleen. Sarcomas appeared to arise in the splenic red pulp or splenic capsule, usually in association with areas of parenchymal and capsular fibrosis and pigmentation. Larger tumors metastasized to the peritoneal cavity and abdominal organs. In some rats there was marked osseous metaplasia when the primary tumor metastasized to peritoneal surfaces. Other, less common, splenic neoplasms included hemangiosarcoma and hemangiopericytoma. Some rats had such extensive peritoneal involvement that the site of origin of their sarcoma was difficult to determine.
AB - In six carcinogenicity bioassays, male and female F344 rats were fed diets containing aniline hydrochloride (CAS: 142-04-1; hydrochloride benzenamide), p-chloroaniline (CAS: 106-47-8), azobenzene (CAS: 103-33-3), o-toluidine hydrochloride (CAS: 636-21-5), dapsone (CAS: 80-08-0; 4, 4′-sulfonyldianiline), or D & C red No. 9 [CAS: D85500000; 5-chloro-2-((2-hydroxy-1-naphthalenyl)azo)-4-methylbenzenesulfonic acid, barium salt]. The rats, from 6 weeks to 2 years old, were given the compounds at two dose levels, the estimated maximum tolerated dose and one-half that dose. In all six bioassays, dose-dependent incidences of splenic sarcomas and fibrosis were seen, with the highest incidences in male rats. Fibrosis occurred in the splenic parenchyma and/or the capsule. Fatty infiltration also was seen in the spleen. Sarcomas appeared to arise in the splenic red pulp or splenic capsule, usually in association with areas of parenchymal and capsular fibrosis and pigmentation. Larger tumors metastasized to the peritoneal cavity and abdominal organs. In some rats there was marked osseous metaplasia when the primary tumor metastasized to peritoneal surfaces. Other, less common, splenic neoplasms included hemangiosarcoma and hemangiopericytoma. Some rats had such extensive peritoneal involvement that the site of origin of their sarcoma was difficult to determine.
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U2 - 10.1093/jnci/73.1.265
DO - 10.1093/jnci/73.1.265
M3 - Article
C2 - 6588231
AN - SCOPUS:0021257162
SN - 0027-8874
VL - 73
SP - 265
EP - 273
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 1
ER -