Spironolactone in the treatment of hirsutism.

L. Anttila, K. Ruutiainen, R. Erkkola

Research output: Contribution to journalArticlepeer-review


Clinical and laboratory studies were performed in 18 hirsute women for evaluation of the efficacy of spironolactone (S) therapy. Each patient received S 100 mg daily. The grade of hirsutism was assessed using a semiquantitative scale of Ferriman and Gallwey. Total testosterone, androstendione, dehydroepiandrosterone sulphate and sexhormone binding globulin were measured before initiation and after six months of therapy. A clinical response was seen in 12 women. The total score of hirsutism in the whole patient group was decreased from 14.1 +/- 6.3 (mean +/- S.D.) to 11.8 +/- 6.4 (p less than 0.01). No changes were found in the hormonal values. The findings of the present study confirm the efficacy of S in decreasing the hair growth by mainly a peripheral mode of action.

Original languageEnglish (US)
Pages (from-to)32-34
Number of pages3
JournalAnnales chirurgiae et gynaecologiae. Supplementum
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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