Spiral waves and rotors: computational and experimental models of cardiac arrhythmias

Nitish V. Thakor, Matthew G. Fishler

Research output: Contribution to journalConference articlepeer-review

Abstract

Spiral waves and rotors have been shown to constitute self-sustaining arrhythmias such as ventricular tachycardia (VT) and fibrillation (VF). An experiment is set up on a slice of cardiac tissue and spiral waves are electrically generated. An analogous model has been created on a super computer using a detailed description of the ion channel currents and membrane voltages and numerical solution of action potential generation and propagation. A voltage sensitive dye is used to image the optical fluorescence resulting from electrical activation of the cardiac tissue. These computational and experimental studies are employed to study the mechanism of induction of arrhythmias and strategies for their termination by defibrillation shock therapy.

Original languageEnglish (US)
Pages (from-to)2601-2603
Number of pages3
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume6
StatePublished - Dec 1 1997
EventProceedings of the 1997 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Chicago, IL, USA
Duration: Oct 30 1997Nov 2 1997

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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