Spindle-cell variant of primary cutaneous follicle center lymphoma spreading to the hepatobiliary tree, mimicking Klatskin tumor

Sima Rozati, Katrin Kerl, Werner Kempf, Marianne Tinguely, Dieter R. Zimmermann, Reinhard Dummer, Antonio Cozzio

Research output: Contribution to journalArticlepeer-review

Abstract

Primary cutaneous follicle center lymphoma (pcFCL) is an indolent type of primary cutaneous B-cell lymphoma (pcBCL) rarely disseminating to other organs. PcBCL with spindle-cell morphology has been described as a rare variant of pcFCL but the prognosis data of this variant is sparse. We report a rare case of spindle-cell pcFCL with CD20+, CD79a+, CD3+, Bcl-6+, Mum-1- and CD10-tumor cells that infiltrated the hepatic hilum, mimicking a Klatskin tumor. On the basis of the sparse published data on spindle-cell morphology of pcBCL, this growth pattern should elicit awareness of an increased risk of systemic involvement in the otherwise indolent pcFCL.

Original languageEnglish (US)
Pages (from-to)56-60
Number of pages5
JournalJournal of Cutaneous Pathology
Volume40
Issue number1
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Keywords

  • Klatskin mimicking tumor
  • cutaneous B-cell lymphoma
  • cutaneous spindle-cell lymphoma
  • hilar cholangiocarcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

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