Spinal muscular atrophy, John Griffin, and mentorship.

Research output: Contribution to journalArticle

Abstract

Hereditary canine spinal muscular atrophy is an inherited motor neuron disease that occurs in Brittany Spaniels and has remarkable similarities with human spinal muscular atrophy. Both disorders are characterized by proximal limb and truncal muscle weakness of variable severity. Detailed pathological studies indicate that there is early dysfunction of motor neuron synapses, particularly the neuromuscular junction synapse, prior to motor neuron death. This period of synaptic dysfunction may define a critical window of opportunity for disease reversibility in motor neuron disease.

Original languageEnglish (US)
Pages (from-to)52-56
Number of pages5
JournalJournal of the Peripheral Nervous System
Volume17 Suppl 3
DOIs
StatePublished - Dec 2012

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Spinal Muscular Atrophy
Motor Neuron Disease
Mentors
Motor Neurons
Synapses
Neuromuscular Junction
Muscle Weakness
Canidae
Extremities

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Spinal muscular atrophy, John Griffin, and mentorship. / Sumner, Charlotte.

In: Journal of the Peripheral Nervous System, Vol. 17 Suppl 3, 12.2012, p. 52-56.

Research output: Contribution to journalArticle

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