Spinal drug delivery

Theodore S. Grabow, David Derdzinski, Peter S. Staats

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Clinicians currently base decisions regarding the use of intrathecal drug therapy for chronic pain on reports from uncontrolled and retrospective studies that fail to rely on standardized outcome measures. In this article, we summarize what is known about currently administered intrathecal therapies, including opioids, gamma-aminobutyric acid agonists, alpha-2 adrenoreceptor agonists, local anesthetics (sodium channel antagonists), calcium channel antagonists, miscellaneous agents, and drug combination therapy. In addition, we offer a brief look at novel approaches that may revolutionize intrathecal drug delivery.

Original languageEnglish (US)
Pages (from-to)510-516
Number of pages7
JournalCurrent pain and headache reports
Issue number6
StatePublished - Dec 2001
Externally publishedYes


  • Baclofen
  • Bupivacaine
  • Cancer Pain
  • Morphine
  • Neuropathic Pain

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine


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