TY - JOUR
T1 - Spinal Cord Stimulation for Pain Treatment After Spinal Cord Injury
AU - Huang, Qian
AU - Duan, Wanru
AU - Sivanesan, Eellan
AU - Liu, Shuguang
AU - Yang, Fei
AU - Chen, Zhiyong
AU - Ford, Neil C.
AU - Chen, Xueming
AU - Guan, Yun
N1 - Funding Information:
This review was supported by grants from the National Institutes of Health, Bethesda, MD (R01NS70814 and R21NS99879 to YG). The authors thank Claire F. Levine, MS, ELS (Scientific Editor, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University) for editing the manuscript.
Funding Information:
Acknowledgements This review was supported by grants from the National Institutes of Health, Bethesda, MD (R01NS70814 and R21NS99879 to YG). The authors thank Claire F. Levine, MS, ELS (Scientific Editor, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University) for editing the manuscript.
Publisher Copyright:
© 2018, Shanghai Institutes for Biological Sciences, CAS.
PY - 2019/6/3
Y1 - 2019/6/3
N2 - In addition to restoration of bladder, bowel, and motor functions, alleviating the accompanying debilitating pain is equally important for improving the quality of life of patients with spinal cord injury (SCI). Currently, however, the treatment of chronic pain after SCI remains a largely unmet need. Electrical spinal cord stimulation (SCS) has been used to manage a variety of chronic pain conditions that are refractory to pharmacotherapy. Yet, its efficacy, benefit profiles, and mechanisms of action in SCI pain remain elusive, due to limited research, methodological weaknesses in previous clinical studies, and a lack of mechanistic exploration of SCS for SCI pain control. We aim to review recent studies and outline the therapeutic potential of different SCS paradigms for traumatic SCI pain. We begin with an overview of its manifestations, classification, potential underlying etiology, and current challenges for its treatment. The clinical evidence for using SCS in SCI pain is then reviewed. Finally, future perspectives of pre-clinical research and clinical study of SCS for SCI pain treatment are discussed.
AB - In addition to restoration of bladder, bowel, and motor functions, alleviating the accompanying debilitating pain is equally important for improving the quality of life of patients with spinal cord injury (SCI). Currently, however, the treatment of chronic pain after SCI remains a largely unmet need. Electrical spinal cord stimulation (SCS) has been used to manage a variety of chronic pain conditions that are refractory to pharmacotherapy. Yet, its efficacy, benefit profiles, and mechanisms of action in SCI pain remain elusive, due to limited research, methodological weaknesses in previous clinical studies, and a lack of mechanistic exploration of SCS for SCI pain control. We aim to review recent studies and outline the therapeutic potential of different SCS paradigms for traumatic SCI pain. We begin with an overview of its manifestations, classification, potential underlying etiology, and current challenges for its treatment. The clinical evidence for using SCS in SCI pain is then reviewed. Finally, future perspectives of pre-clinical research and clinical study of SCS for SCI pain treatment are discussed.
KW - Analgesia
KW - Neuromodulation
KW - Pain
KW - Spinal cord injury
KW - Spinal cord stimulation
KW - Trauma
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U2 - 10.1007/s12264-018-0320-9
DO - 10.1007/s12264-018-0320-9
M3 - Review article
C2 - 30560438
AN - SCOPUS:85058688867
VL - 35
SP - 527
EP - 539
JO - Neuroscience Bulletin
JF - Neuroscience Bulletin
SN - 1673-7067
IS - 3
ER -