Spinal Cord MRI in Multiple Sclerosis

Alexandra Muccilli; Estelle Seyman; Jiwon Oh

doi:10.1016/j.ncl.2017.08.009

Spinal Cord MRI in Multiple Sclerosis

Alexandra Muccilli, Estelle Seyman, Jiwon Oh

School of Medicine

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Spinal cord (SC) MRI in multiple sclerosis (MS) has significant usefulness in clinical and investigational settings. Conventional MRI of the SC is used in clinical practice, because it has both diagnostic and prognostic value. A number of advanced, quantitative SC MRI measures that assess the structural and functional integrity of the SC have been evaluated in investigational settings. These techniques have collectively demonstrated usefulness in providing insight into microstructural and functional changes relevant to disability in MS. With further development, these techniques may be useful in clinical trial settings as biomarkers of neurodegeneration and protection, and in day-to-day clinical practice.

Original language	English (US)
Pages (from-to)	35-57
Number of pages	23
Journal	Neurologic clinics
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/j.ncl.2017.08.009
State	Published - Feb 2018

Keywords

Clinical usefulness
MRI
Multiple sclerosis
Prediction
Quantitative techniques
Spinal cord

ASJC Scopus subject areas

Clinical Neurology

Access to Document

10.1016/j.ncl.2017.08.009

Cite this

@article{a1c66445e3ac425195b89945817ec732,

title = "Spinal Cord MRI in Multiple Sclerosis",

abstract = "Spinal cord (SC) MRI in multiple sclerosis (MS) has significant usefulness in clinical and investigational settings. Conventional MRI of the SC is used in clinical practice, because it has both diagnostic and prognostic value. A number of advanced, quantitative SC MRI measures that assess the structural and functional integrity of the SC have been evaluated in investigational settings. These techniques have collectively demonstrated usefulness in providing insight into microstructural and functional changes relevant to disability in MS. With further development, these techniques may be useful in clinical trial settings as biomarkers of neurodegeneration and protection, and in day-to-day clinical practice.",

keywords = "Clinical usefulness, MRI, Multiple sclerosis, Prediction, Quantitative techniques, Spinal cord",

author = "Alexandra Muccilli and Estelle Seyman and Jiwon Oh",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2018",

month = feb,

doi = "10.1016/j.ncl.2017.08.009",

language = "English (US)",

volume = "36",

pages = "35--57",

journal = "Neurologic clinics",

issn = "0733-8619",

publisher = "W.B. Saunders Ltd",

number = "1",

}

TY - JOUR

T1 - Spinal Cord MRI in Multiple Sclerosis

AU - Muccilli, Alexandra

AU - Seyman, Estelle

AU - Oh, Jiwon

PY - 2018/2

Y1 - 2018/2

N2 - Spinal cord (SC) MRI in multiple sclerosis (MS) has significant usefulness in clinical and investigational settings. Conventional MRI of the SC is used in clinical practice, because it has both diagnostic and prognostic value. A number of advanced, quantitative SC MRI measures that assess the structural and functional integrity of the SC have been evaluated in investigational settings. These techniques have collectively demonstrated usefulness in providing insight into microstructural and functional changes relevant to disability in MS. With further development, these techniques may be useful in clinical trial settings as biomarkers of neurodegeneration and protection, and in day-to-day clinical practice.

AB - Spinal cord (SC) MRI in multiple sclerosis (MS) has significant usefulness in clinical and investigational settings. Conventional MRI of the SC is used in clinical practice, because it has both diagnostic and prognostic value. A number of advanced, quantitative SC MRI measures that assess the structural and functional integrity of the SC have been evaluated in investigational settings. These techniques have collectively demonstrated usefulness in providing insight into microstructural and functional changes relevant to disability in MS. With further development, these techniques may be useful in clinical trial settings as biomarkers of neurodegeneration and protection, and in day-to-day clinical practice.

KW - Clinical usefulness

KW - MRI

KW - Multiple sclerosis

KW - Prediction

KW - Quantitative techniques

KW - Spinal cord

UR - http://www.scopus.com/inward/record.url?scp=85036644310&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85036644310&partnerID=8YFLogxK

U2 - 10.1016/j.ncl.2017.08.009

DO - 10.1016/j.ncl.2017.08.009

M3 - Review article

C2 - 29157403

AN - SCOPUS:85036644310

SN - 0733-8619

VL - 36

SP - 35

EP - 57

JO - Neurologic clinics

JF - Neurologic clinics

IS - 1

ER -

Spinal Cord MRI in Multiple Sclerosis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this