Abstract
Spinal cord involvement is an important cause of disability in patients with multiple sclerosis or neuromyelitis optica spectrum disorders (NMOSDs). Multiple sclerosis and NMOSDs can be distinguished from other disorders that cause myelopathy by results from laboratory and radiological investigations. However, limitations in the sensitivity and specificity of spinal cord imaging and poor correlation with disability megasures have impeded the understanding of the relationship between spinal cord involvement and clinical manifestations. Nevertheless, studies of the pathological features of multiple sclerosis and NMOSDs have shown that quantitatively different mechanisms lead to differences in clinical course and pattern of accrual of permanent disability in the two disorders. Better understanding of these mechanisms is necessary to develop more informative clinical measures, electrophysiological methods, fluid biomarkers, and imaging techniques to detect and monitor spinal cord involvement in the diagnosis and management of patients with multiple sclerosis or NMOSDs, and as outcome measures in clinical trials.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 185-197 |
| Number of pages | 13 |
| Journal | The Lancet Neurology |
| Volume | 18 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2019 |
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ASJC Scopus subject areas
- Clinical Neurology
Cite this
Spinal cord involvement in multiple sclerosis and neuromyelitis optica spectrum disorders. / International Conference on Spinal Cord Involvement and Imaging in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders.
In: The Lancet Neurology, Vol. 18, No. 2, 01.02.2019, p. 185-197.Research output: Contribution to journal › Review article
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TY - JOUR
T1 - Spinal cord involvement in multiple sclerosis and neuromyelitis optica spectrum disorders
AU - International Conference on Spinal Cord Involvement and Imaging in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders
AU - Ciccarelli, Olga
AU - Cohen, Jeffrey A.
AU - Reingold, Stephen C.
AU - Weinshenker, Brian G.
AU - Amato, Maria Pia
AU - Banwell, Brenda
AU - Barkhof, Frederik
AU - Bebo, Bruce
AU - Becher, Burkhard
AU - Bethoux, François
AU - Brandt, Alexander
AU - Brownlee, Wallace
AU - Calabresi, Peter
AU - Chatway, Jeremy
AU - Chien, Claudia
AU - Chitnis, Tanuja
AU - Cohen, Jeffrey
AU - Comi, Giancarlo
AU - Correale, Jorge
AU - De Sèze, Jerome
AU - De Stefano, Nicola
AU - Fazekas, Franz
AU - Flanagan, Eoin
AU - Freedman, Mark
AU - Fujihara, Kazuo
AU - Galetta, Steven
AU - Goldman, Myla
AU - Greenberg, Benjamin
AU - Hartung, Hans Peter
AU - Hemmer, Bernhard
AU - Henning, Anke
AU - Izbudak, Izlem
AU - Kappos, Ludwig
AU - Lassmann, Hans
AU - Laule, Cornelia
AU - Levy, Michael
AU - Lublin, Fred
AU - Lucchinetti, Claudia
AU - Lukas, Carsten
AU - Marrie, Ruth Ann
AU - Miller, Aaron
AU - Miller, David
AU - Montalban, Xavier
AU - Mowry, Ellen Mahar
AU - Ourselin, Sebastien
AU - Paul, Friedemann
AU - Pelletier, Daniel
AU - Ranjeva, Jean Philippe
AU - Reich, Daniel
AU - Reingold, Stephen
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Spinal cord involvement is an important cause of disability in patients with multiple sclerosis or neuromyelitis optica spectrum disorders (NMOSDs). Multiple sclerosis and NMOSDs can be distinguished from other disorders that cause myelopathy by results from laboratory and radiological investigations. However, limitations in the sensitivity and specificity of spinal cord imaging and poor correlation with disability megasures have impeded the understanding of the relationship between spinal cord involvement and clinical manifestations. Nevertheless, studies of the pathological features of multiple sclerosis and NMOSDs have shown that quantitatively different mechanisms lead to differences in clinical course and pattern of accrual of permanent disability in the two disorders. Better understanding of these mechanisms is necessary to develop more informative clinical measures, electrophysiological methods, fluid biomarkers, and imaging techniques to detect and monitor spinal cord involvement in the diagnosis and management of patients with multiple sclerosis or NMOSDs, and as outcome measures in clinical trials.
AB - Spinal cord involvement is an important cause of disability in patients with multiple sclerosis or neuromyelitis optica spectrum disorders (NMOSDs). Multiple sclerosis and NMOSDs can be distinguished from other disorders that cause myelopathy by results from laboratory and radiological investigations. However, limitations in the sensitivity and specificity of spinal cord imaging and poor correlation with disability megasures have impeded the understanding of the relationship between spinal cord involvement and clinical manifestations. Nevertheless, studies of the pathological features of multiple sclerosis and NMOSDs have shown that quantitatively different mechanisms lead to differences in clinical course and pattern of accrual of permanent disability in the two disorders. Better understanding of these mechanisms is necessary to develop more informative clinical measures, electrophysiological methods, fluid biomarkers, and imaging techniques to detect and monitor spinal cord involvement in the diagnosis and management of patients with multiple sclerosis or NMOSDs, and as outcome measures in clinical trials.
UR - http://www.scopus.com/inward/record.url?scp=85060049167&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85060049167&partnerID=8YFLogxK
U2 - 10.1016/S1474-4422(18)30460-5
DO - 10.1016/S1474-4422(18)30460-5
M3 - Review article
C2 - 30663608
AN - SCOPUS:85060049167
VL - 18
SP - 185
EP - 197
JO - The Lancet Neurology
JF - The Lancet Neurology
SN - 1474-4422
IS - 2
ER -