Spinal Cord Injury Detection and Monitoring Using Spectral Coherence

Hasan Al-Nashash, Noreen A. Fatoo, Nabil N. Mirza, Rabi I. Ahmed, Gracee Agrawal, Angelo H. All, Nitish V. Thakor

Research output: Contribution to journalArticle

Abstract

In this paper, spectral coherence (SC) is used to study the somatosensory evoked potential (SEP) signals in rodent model before and after spinal cord injury (SCI). The SC technique is complemented with the Basso, Beattie, and Bresnahan (BBB) behavior analysis method to help us assess the status of the motor recovery. SC can be used to follow the effects of SCI without any preinjury baseline information. In this study, adult female Fischer rats received contusion injury at T8 level with varying impact heights using the standard New York University impactor. The results show that the average SC between forelimb and hindlimb SEP signals before injury was relatively high (≥0.7). Following injury, the SC between the forelimb and hindlimb SEP signals dropped to various levels (≤0.7) corresponding to the severity of SCI. The SC analysis gave normalized quantifiable results for the evaluation of SCI and recovery thereafter using the forelimb signals as an effective control, without the need of any baseline data. This technique solves the problems associated with the commonly used time-domain analysis like the need of a trained neurophysiologist to interpret the data and the need for baseline data. We believe that both SC and BBB may provide a comprehensive and complementary picture of the health status of the spinal cord after injury. The presented method is applicable to SCIs not affecting the forelimb SEP signals.

Original languageEnglish (US)
Pages (from-to)1971-1979
Number of pages9
JournalIEEE Transactions on Biomedical Engineering
Volume56
Issue number8
DOIs
StatePublished - Aug 2009

Keywords

  • Basso
  • Beattie and Bresnahan (BBB) score
  • New York University (NYU) impactor
  • somatosensory evoked potentials (SEPs)
  • spectral coherence (SC)
  • spinal cord injury (SCI)

ASJC Scopus subject areas

  • Biomedical Engineering

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