Spinal Cord Injury

John W. McDonald, Daniel Becker

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter focuses on embryonic stem (ES) cells as an important research tool and potential therapy. The chapter reviews studies that have used ES cells in spinal cord repair and concludes that progress has been good, that knowledge is still too limited, and that harnessing the potential of ES cells will be important for solving the problem of spinal cord injury (SCI). SCI is a major medical problem, because there is currently no way to repair the central nervous system (CNS) and restore function. Early animal studies showed that mouse ES cells can replace neurons, astrocytes, and oligodendrocytes; instigate appropriate remyelination; and even improve locomotion. As is the case for all transplantation studies, the mechanisms underlying functional improvement remain unclear. ES cells offer a novel approach to deciphering these mechanisms. It is clear that murine and human ES cells are tools that will revolutionize neurobiology and neural transplantation, by providing the unprecedented ability to selectively deliver key regulatory factors. ES cells promise to be one of the greatest therapies for chronic nervous system disorders. It can be said with confidence that ES cells will have a major effect on repairing the human CNS. © 2009

Original languageEnglish (US)
Title of host publicationEssentials of Stem Cell Biology
PublisherElsevier Inc.
Pages497-506
Number of pages10
ISBN (Print)9780123747297
DOIs
StatePublished - 2009

Fingerprint

Embryonic Stem Cells
Stem cells
Spinal Cord Injuries
Neurology
Central Nervous System
Transplantation
Spinal Cord Regeneration
Aptitude
Repair
Neurobiology
Oligodendroglia
Locomotion
Nervous System Diseases
Astrocytes
Medical problems
Neurons
Animals
Therapeutics
Research

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

McDonald, J. W., & Becker, D. (2009). Spinal Cord Injury. In Essentials of Stem Cell Biology (pp. 497-506). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374729-7.00055-X

Spinal Cord Injury. / McDonald, John W.; Becker, Daniel.

Essentials of Stem Cell Biology. Elsevier Inc., 2009. p. 497-506.

Research output: Chapter in Book/Report/Conference proceedingChapter

McDonald, JW & Becker, D 2009, Spinal Cord Injury. in Essentials of Stem Cell Biology. Elsevier Inc., pp. 497-506. https://doi.org/10.1016/B978-0-12-374729-7.00055-X
McDonald JW, Becker D. Spinal Cord Injury. In Essentials of Stem Cell Biology. Elsevier Inc. 2009. p. 497-506 https://doi.org/10.1016/B978-0-12-374729-7.00055-X
McDonald, John W. ; Becker, Daniel. / Spinal Cord Injury. Essentials of Stem Cell Biology. Elsevier Inc., 2009. pp. 497-506
@inbook{4c29c1cd14ea47d8bd17bdae4b30e6fc,
title = "Spinal Cord Injury",
abstract = "This chapter focuses on embryonic stem (ES) cells as an important research tool and potential therapy. The chapter reviews studies that have used ES cells in spinal cord repair and concludes that progress has been good, that knowledge is still too limited, and that harnessing the potential of ES cells will be important for solving the problem of spinal cord injury (SCI). SCI is a major medical problem, because there is currently no way to repair the central nervous system (CNS) and restore function. Early animal studies showed that mouse ES cells can replace neurons, astrocytes, and oligodendrocytes; instigate appropriate remyelination; and even improve locomotion. As is the case for all transplantation studies, the mechanisms underlying functional improvement remain unclear. ES cells offer a novel approach to deciphering these mechanisms. It is clear that murine and human ES cells are tools that will revolutionize neurobiology and neural transplantation, by providing the unprecedented ability to selectively deliver key regulatory factors. ES cells promise to be one of the greatest therapies for chronic nervous system disorders. It can be said with confidence that ES cells will have a major effect on repairing the human CNS. {\circledC} 2009",
author = "McDonald, {John W.} and Daniel Becker",
year = "2009",
doi = "10.1016/B978-0-12-374729-7.00055-X",
language = "English (US)",
isbn = "9780123747297",
pages = "497--506",
booktitle = "Essentials of Stem Cell Biology",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Spinal Cord Injury

AU - McDonald, John W.

AU - Becker, Daniel

PY - 2009

Y1 - 2009

N2 - This chapter focuses on embryonic stem (ES) cells as an important research tool and potential therapy. The chapter reviews studies that have used ES cells in spinal cord repair and concludes that progress has been good, that knowledge is still too limited, and that harnessing the potential of ES cells will be important for solving the problem of spinal cord injury (SCI). SCI is a major medical problem, because there is currently no way to repair the central nervous system (CNS) and restore function. Early animal studies showed that mouse ES cells can replace neurons, astrocytes, and oligodendrocytes; instigate appropriate remyelination; and even improve locomotion. As is the case for all transplantation studies, the mechanisms underlying functional improvement remain unclear. ES cells offer a novel approach to deciphering these mechanisms. It is clear that murine and human ES cells are tools that will revolutionize neurobiology and neural transplantation, by providing the unprecedented ability to selectively deliver key regulatory factors. ES cells promise to be one of the greatest therapies for chronic nervous system disorders. It can be said with confidence that ES cells will have a major effect on repairing the human CNS. © 2009

AB - This chapter focuses on embryonic stem (ES) cells as an important research tool and potential therapy. The chapter reviews studies that have used ES cells in spinal cord repair and concludes that progress has been good, that knowledge is still too limited, and that harnessing the potential of ES cells will be important for solving the problem of spinal cord injury (SCI). SCI is a major medical problem, because there is currently no way to repair the central nervous system (CNS) and restore function. Early animal studies showed that mouse ES cells can replace neurons, astrocytes, and oligodendrocytes; instigate appropriate remyelination; and even improve locomotion. As is the case for all transplantation studies, the mechanisms underlying functional improvement remain unclear. ES cells offer a novel approach to deciphering these mechanisms. It is clear that murine and human ES cells are tools that will revolutionize neurobiology and neural transplantation, by providing the unprecedented ability to selectively deliver key regulatory factors. ES cells promise to be one of the greatest therapies for chronic nervous system disorders. It can be said with confidence that ES cells will have a major effect on repairing the human CNS. © 2009

UR - http://www.scopus.com/inward/record.url?scp=84882537309&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882537309&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-374729-7.00055-X

DO - 10.1016/B978-0-12-374729-7.00055-X

M3 - Chapter

AN - SCOPUS:84882537309

SN - 9780123747297

SP - 497

EP - 506

BT - Essentials of Stem Cell Biology

PB - Elsevier Inc.

ER -