TY - CHAP
T1 - Spinal Cord Injury
AU - McDonald, John W.
AU - Becker, Daniel
AU - Huettner, James
N1 - Funding Information:
We would like to thank the people in my laboratory who have contributed to this work over the years and also my collaborators: Jeff Bulte at the National Institutes of Health (NHI) and Dennis W. Choi, David I. Gottlieb, David Gutmann, Chung Hsu, Mark F. Jacquin, Gene Johnson, and Carl Lauryssen at Washington University in St. Louis. This team obtained a program project grant from the NIH (NS39577) to evaluate the potential of ES cells to repair SCI. We would also like to thank our animal technicians who express rodent bladders three times daily, 7 days a week, including holidays (Joan Bonnot, Joseph Galvez, Brandy Jones, and Amy Hansen) and our TC staff who passage ES cells every other day endlessly (Ashley Johnson, Laura Luecking, and Becky Purcell). This work was supported by NINDS and NIDCR grants NS39577, NS40520, NS45023, DE07734, and NS045023.
Publisher Copyright:
© 2004 Elsevier Inc. All rights reserved.
PY - 2004/9/14
Y1 - 2004/9/14
N2 - Spinal cord injury (SCI) is a major medical problem, because there currently is no way to repair the central nervous system (CNS) and restore its function. This chapter focuses on embryonic stem (ES) cells as an important research tool and potential therapy. It reviews the epidemiology, functional anatomy, and pathophysiology of SCI, and describes spontaneous regeneration and limitations on repair. There are four to five times as many spinal cord injuries caused by medical conditions as well, such as multiple sclerosis, a common disorder that destroys the myelin insulation on nerves in the cervical spinal cord. Unlike the brain, the spinal cord has its white matter on the outside and gray matter on the inside. The outer white matter also contains astrocytes and blood vessels, but it consists mostly of axons and oligodendrocytes glial cells that wrap axons in white, insulated myelin. Evidence suggests that factors in the CNS actively inhibit regeneration; such factors include inhibitory proteins in the cord, which guide regrowing connections, and scar tissue, which contains chondroitin sulfate and proteoglycans. Reduced production of growth factors that stimulate regrowth also limits regeneration. To understand spinal cord regeneration, it is necessary to understand spinal cord development. Transplantation of genetically modified cells contributes to repair and recovery from spinal injury.
AB - Spinal cord injury (SCI) is a major medical problem, because there currently is no way to repair the central nervous system (CNS) and restore its function. This chapter focuses on embryonic stem (ES) cells as an important research tool and potential therapy. It reviews the epidemiology, functional anatomy, and pathophysiology of SCI, and describes spontaneous regeneration and limitations on repair. There are four to five times as many spinal cord injuries caused by medical conditions as well, such as multiple sclerosis, a common disorder that destroys the myelin insulation on nerves in the cervical spinal cord. Unlike the brain, the spinal cord has its white matter on the outside and gray matter on the inside. The outer white matter also contains astrocytes and blood vessels, but it consists mostly of axons and oligodendrocytes glial cells that wrap axons in white, insulated myelin. Evidence suggests that factors in the CNS actively inhibit regeneration; such factors include inhibitory proteins in the cord, which guide regrowing connections, and scar tissue, which contains chondroitin sulfate and proteoglycans. Reduced production of growth factors that stimulate regrowth also limits regeneration. To understand spinal cord regeneration, it is necessary to understand spinal cord development. Transplantation of genetically modified cells contributes to repair and recovery from spinal injury.
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U2 - 10.1016/B978-012436643-5/50078-X
DO - 10.1016/B978-012436643-5/50078-X
M3 - Chapter
AN - SCOPUS:84868153760
SN - 9780124366435
VL - 1
SP - 701
EP - 712
BT - Embryonic
PB - Elsevier Inc.
ER -