Specular microscopy of iridocorneal endothelia syndrome

Lawrence W. Hirst, Harry A. Quigley, Walter J. Stark, M. Bruce Shields

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Clinical specular microscopic examination of 17 patients with features common to the iridocorneal endothelial syndrome (including Chandler's syndrome, iris nevus syndrome, and essential iris atrophy) showed pathognomonic endothelial changes and no areas of normal endothelial mosaic. Even in those patients with minimal anterior synechiae, gross central endothelial changes could be found, suggesting that the endothelial changes are primary and not secondary to the iriscorneal adhesions. Specular microscopy of the clinically uninvolved contralateral eye in these patients revealed frequent endothelial cell pleomorphism incommensurate with the patient's age. This study also confirmed the value of the specular microscope for qualitative endothelial observations.

Original languageEnglish (US)
Pages (from-to)11-21
Number of pages11
JournalAmerican journal of ophthalmology
Issue number1
StatePublished - Jan 1980

ASJC Scopus subject areas

  • Ophthalmology


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