SPECTRAL QUANTIFICATION OF MORPHINE- AND CLONIDINE-INDUCED EEG CHANGES IN THE DOG.

Vaikunth N. Gupta, Wallace B. Pickworth

Research output: Contribution to conferencePaperpeer-review

Abstract

In a previous publication, it was reported that clonidine and morphine caused similar effects in the behavior of EEG of the unrestrained intact dog. In that study, EEG was visually analyzed. In the present study, spectral techniques were used to compare cortical EEG changes induced by morphine and clonidine. In experiments, the variability in randomly chosen EEG sweeps obscured the drug effects and precluded the use of parametric statistics. Therefore, six selected EEG sweeps before intravenous drug infusion and at peak drug effect were analyzed by fast Fourier transform routines to obtain power spectral density estimates at 1 Hz resolution. The spectral estimates were averaged on a computer. Morphine (1 mg/kg) and clonidine (100 mu g/kg) increased total power in the parietal and occipital EEG over the frequency range 0. 3-20 Hz. The increase in spectral power was at least fivefold over the frequency bands 8 - 16 Hz. Both drugs caused an increase in the peak freuency. The quantitative similarity of the morphine and clonidine effects support the hypothesis that these drugs cause EEG synchrony by actions on the same or parallel neural pathways.

Original languageEnglish (US)
Pages257-259
Number of pages3
StatePublished - 1980
Externally publishedYes
EventIEEE/Eng Med Biol Soc Annu Conf 2nd, Front of Eng in Health Care - Washington, DC, USA
Duration: Sep 28 1980Sep 30 1980

Other

OtherIEEE/Eng Med Biol Soc Annu Conf 2nd, Front of Eng in Health Care
CityWashington, DC, USA
Period9/28/809/30/80

ASJC Scopus subject areas

  • Engineering(all)

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