Spectral editing in 1H magnetic resonance spectroscopy: Experts' consensus recommendations

In Young Choi, Ovidiu C. Andronesi, Peter Barker, Wolfgang Bogner, Richard A.E. Edden, Lana G. Kaiser, Phil Lee, Małgorzata Marjańska, Melissa Terpstra, Robin A. de Graaf

Research output: Contribution to journalReview articlepeer-review


Spectral editing in in vivo 1H-MRS provides an effective means to measure low-concentration metabolite signals that cannot be reliably measured by conventional MRS techniques due to signal overlap, for example, γ-aminobutyric acid, glutathione and D-2-hydroxyglutarate. Spectral editing strategies utilize known J-coupling relationships within the metabolite of interest to discriminate their resonances from overlying signals. This consensus recommendation paper provides a brief overview of commonly used homonuclear editing techniques and considerations for data acquisition, processing and quantification. Also, we have listed the experts' recommendations for minimum requirements to achieve adequate spectral editing and reliable quantification. These include selecting the right editing sequence, dealing with frequency drift, handling unwanted coedited resonances, spectral fitting of edited spectra, setting up multicenter clinical trials and recommending sequence parameters to be reported in publications.

Original languageEnglish (US)
Article numbere4411
JournalNMR in biomedicine
Issue number5
StatePublished - May 2021


  • J-difference editing
  • consensus recommendations
  • multiple quantum filtering
  • spectral editing
  • γ-aminobutyric acid, glutathione

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy


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