Spectral domain optical coherence tomography findings in acute syphilitic posterior placoid chorioretinitis

Bryn M. Burkholder, Theresa G. Leung, Trucian A. Ostheimer, Nicholas J. Butler, Jennifer E. Thorne, James P. Dunn

Research output: Contribution to journalArticle

Abstract

Background: We describe the spectral domain optical coherence tomography (SD-OCT) findings in three patients with acute syphilitic posterior placoid chorioretinitis (ASPPC). The SD-OCT images demonstrate the pathologic changes in ASPPC with a high level of anatomic detail and may provide information about the pathophysiology of the disease. Findings: We report a series of three consecutive patients seen at the Wilmer Eye Institute in 2012 and 2013 who presented with clinical and laboratory findings consistent with a diagnosis of unilateral ASPPC. Two of the three patients had HIV co-infection with good immune recovery. SD-OCT images from their initial (pre-treatment) presentation demonstrated thickening and hyperreflective nodularity of the choroid-retinal pigment epithelium (RPE) complex, with focal disruption of the overlying photoreceptor inner segment-outer segment junction in the areas corresponding to the retinal lesions seen on clinical examination. These changes improved with intravenous antibiotic treatment over a 3-month period of follow-up. Conclusions: SD-OCT imaging in ASPPC demonstrates reversible, focal thickening, and nodularity of the RPE with disruption of the overlying photoreceptor inner segment-outer segment junction. We believe that these SD-OCT images support the concept that ASPPC involves an inflammatory process at the level of the choroid-RPE with resultant structural and functional changes in the retinal photoreceptors. Further study with OCT imaging may be helpful in better understanding this disease.

Original languageEnglish (US)
Article number2
Pages (from-to)1-5
Number of pages5
JournalJournal of Ophthalmic Inflammation and Infection
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2014

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Keywords

  • Chorioretinis
  • Optical coherence tomography
  • Photoreceptor
  • Retinal pigment epithelium
  • Syphilis

ASJC Scopus subject areas

  • Ophthalmology
  • Infectious Diseases

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