Spectral correlation of action potential firing rates after hypoxic-ischemic brain injury

Jitendran Muthuswamy, David L. Sherman, Melvin J. Hinich, Daniel F. Hanley, Nitish V. Thakor

Research output: Contribution to journalConference article

Abstract

During recovery from hypoxia-ischemic (HI) injury microelectrode recordings of multiple action potentials from thalamus exhibit periodic oscillations. Firing rate variability analysis reveals that spike frequency is periodically modulated by a low frequency oscillation called spindle. This leads to spectral self-coherences among firing rate components during spindle episodes. In an animal model of cerebral injury we monitor neural responses from the VPL (ventral-posterior lateral) thalamic nucleus after 3 min of total asphyxia. Spindling episodes of VPL multiple unit responses appear within the first 5 min of recovery. These spindles modulate the multi-unit activity at the rate of approximately 10 Hz. Interspike intervals (ISI) fluctuate from 2 to 10 ms during these burst periods. Frequency coupling occurs between frequencies in the 100 Hz to 300 Hz range (p<0.01) induced by the spindle envelope. Thus, spectral correlation analysis accurately captures the low frequency modulation of action potentials from a short segment of data.

Original languageEnglish (US)
Pages (from-to)2020-2022
Number of pages3
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume4
StatePublished - Dec 1 1998
EventProceedings of the 1998 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 6) - Hong Kong, China
Duration: Oct 29 1998Nov 1 1998

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Fingerprint Dive into the research topics of 'Spectral correlation of action potential firing rates after hypoxic-ischemic brain injury'. Together they form a unique fingerprint.

Cite this