Spectral analysis using regularized non-negative least-squares estimation

P. Chiao, J. A. Fessler, K. R. Zasadny, R. L. Wahl

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The implementation of spectral analysis techniques involves solving a highly underdetermined linear system equation and is prone to the effect of measurement noise. We propose to use a regularized non-negative least-square estimator to stabilize the implementation of the technique. We introduce a penalty term in our formulation of the objective function to discourage disparities in tracer kinetics between neighboring pixels and use an iterative method to impose positivity constraints. We show results from analysis of FDG thorax images of patients suspected to have cancers and summarize our findings.

Original languageEnglish (US)
Title of host publicationIEEE Nuclear Science Symposium & Medical Imaging Conference
PublisherIEEE
Pages1680-1683
Number of pages4
Volume3
StatePublished - 1995
Externally publishedYes
EventProceedings of the 1995 IEEE Nuclear Science Symposium and Medical Imaging Conference. Part 1 (of 3) - San Francisco, CA, USA
Duration: Oct 21 1995Oct 28 1995

Other

OtherProceedings of the 1995 IEEE Nuclear Science Symposium and Medical Imaging Conference. Part 1 (of 3)
CitySan Francisco, CA, USA
Period10/21/9510/28/95

Fingerprint

Iterative methods
Spectrum analysis
Linear systems
Pixels
Kinetics

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Chiao, P., Fessler, J. A., Zasadny, K. R., & Wahl, R. L. (1995). Spectral analysis using regularized non-negative least-squares estimation. In IEEE Nuclear Science Symposium & Medical Imaging Conference (Vol. 3, pp. 1680-1683). IEEE.

Spectral analysis using regularized non-negative least-squares estimation. / Chiao, P.; Fessler, J. A.; Zasadny, K. R.; Wahl, R. L.

IEEE Nuclear Science Symposium & Medical Imaging Conference. Vol. 3 IEEE, 1995. p. 1680-1683.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chiao, P, Fessler, JA, Zasadny, KR & Wahl, RL 1995, Spectral analysis using regularized non-negative least-squares estimation. in IEEE Nuclear Science Symposium & Medical Imaging Conference. vol. 3, IEEE, pp. 1680-1683, Proceedings of the 1995 IEEE Nuclear Science Symposium and Medical Imaging Conference. Part 1 (of 3), San Francisco, CA, USA, 10/21/95.
Chiao P, Fessler JA, Zasadny KR, Wahl RL. Spectral analysis using regularized non-negative least-squares estimation. In IEEE Nuclear Science Symposium & Medical Imaging Conference. Vol. 3. IEEE. 1995. p. 1680-1683
Chiao, P. ; Fessler, J. A. ; Zasadny, K. R. ; Wahl, R. L. / Spectral analysis using regularized non-negative least-squares estimation. IEEE Nuclear Science Symposium & Medical Imaging Conference. Vol. 3 IEEE, 1995. pp. 1680-1683
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