Abstract
Introduction: In addition to dyscoordination of upper airway dilator muscles activity, sleep may also alter the pattern of intra-muscular activation of single motor units (SMUs). Such changes should be identifiable by a state dependent change in EMG power spectrum, i.e., a shift in centroid frequency (ƒc) during sleep. Methods: EMGs of the genioglossus and four other peri-pharyngeal muscles were recorded in OSA patients (n = 8), age-matched healthy subjects (n = 7), and 5 young healthy subjects, and ƒc was calculated for wakefulness and sleep periods. Results: ƒc decreased with the onset of sleep and returned to baseline levels after arousal. ƒc of all muscles decreased similarly and significantly during sleep in the OSA and the age-matched healthy subjects, but not in the young subjects. Conclusions: The pattern of decrease in ƒc is compatible with altered synchronization of SMUs during sleep. We speculate that these changes may contribute to the failure of dilator muscles to improve flow limitation during sleep in older subjects.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 53-57 |
| Number of pages | 5 |
| Journal | Respiratory Physiology and Neurobiology |
| Volume | 260 |
| DOIs | |
| State | Published - Feb 1 2019 |
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Keywords
- Centroid frequency
- Genioglossus
- Obstructive sleep apnea
- Spectral analysis
- Upper airway
ASJC Scopus subject areas
- Neuroscience(all)
- Physiology
- Pulmonary and Respiratory Medicine
Cite this
Spectral analysis of peri-pharyngeal muscles’ EMG in patients with OSA and healthy subjects. / Oliven, Ron; Cohen, Guy; Somri, Mostafa; Schwartz, Alan R; Oliven, Arie.
In: Respiratory Physiology and Neurobiology, Vol. 260, 01.02.2019, p. 53-57.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Spectral analysis of peri-pharyngeal muscles’ EMG in patients with OSA and healthy subjects
AU - Oliven, Ron
AU - Cohen, Guy
AU - Somri, Mostafa
AU - Schwartz, Alan R
AU - Oliven, Arie
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Introduction: In addition to dyscoordination of upper airway dilator muscles activity, sleep may also alter the pattern of intra-muscular activation of single motor units (SMUs). Such changes should be identifiable by a state dependent change in EMG power spectrum, i.e., a shift in centroid frequency (ƒc) during sleep. Methods: EMGs of the genioglossus and four other peri-pharyngeal muscles were recorded in OSA patients (n = 8), age-matched healthy subjects (n = 7), and 5 young healthy subjects, and ƒc was calculated for wakefulness and sleep periods. Results: ƒc decreased with the onset of sleep and returned to baseline levels after arousal. ƒc of all muscles decreased similarly and significantly during sleep in the OSA and the age-matched healthy subjects, but not in the young subjects. Conclusions: The pattern of decrease in ƒc is compatible with altered synchronization of SMUs during sleep. We speculate that these changes may contribute to the failure of dilator muscles to improve flow limitation during sleep in older subjects.
AB - Introduction: In addition to dyscoordination of upper airway dilator muscles activity, sleep may also alter the pattern of intra-muscular activation of single motor units (SMUs). Such changes should be identifiable by a state dependent change in EMG power spectrum, i.e., a shift in centroid frequency (ƒc) during sleep. Methods: EMGs of the genioglossus and four other peri-pharyngeal muscles were recorded in OSA patients (n = 8), age-matched healthy subjects (n = 7), and 5 young healthy subjects, and ƒc was calculated for wakefulness and sleep periods. Results: ƒc decreased with the onset of sleep and returned to baseline levels after arousal. ƒc of all muscles decreased similarly and significantly during sleep in the OSA and the age-matched healthy subjects, but not in the young subjects. Conclusions: The pattern of decrease in ƒc is compatible with altered synchronization of SMUs during sleep. We speculate that these changes may contribute to the failure of dilator muscles to improve flow limitation during sleep in older subjects.
KW - Centroid frequency
KW - Genioglossus
KW - Obstructive sleep apnea
KW - Spectral analysis
KW - Upper airway
UR - http://www.scopus.com/inward/record.url?scp=85058685313&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85058685313&partnerID=8YFLogxK
U2 - 10.1016/j.resp.2018.12.002
DO - 10.1016/j.resp.2018.12.002
M3 - Article
C2 - 30553943
AN - SCOPUS:85058685313
VL - 260
SP - 53
EP - 57
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
SN - 1569-9048
ER -