Spectral analysis of peri-pharyngeal muscles’ EMG in patients with OSA and healthy subjects

Ron Oliven, Guy Cohen, Mostafa Somri, Alan R Schwartz, Arie Oliven

Research output: Contribution to journalArticle

Abstract

Introduction: In addition to dyscoordination of upper airway dilator muscles activity, sleep may also alter the pattern of intra-muscular activation of single motor units (SMUs). Such changes should be identifiable by a state dependent change in EMG power spectrum, i.e., a shift in centroid frequency (ƒc) during sleep. Methods: EMGs of the genioglossus and four other peri-pharyngeal muscles were recorded in OSA patients (n = 8), age-matched healthy subjects (n = 7), and 5 young healthy subjects, and ƒc was calculated for wakefulness and sleep periods. Results: ƒc decreased with the onset of sleep and returned to baseline levels after arousal. ƒc of all muscles decreased similarly and significantly during sleep in the OSA and the age-matched healthy subjects, but not in the young subjects. Conclusions: The pattern of decrease in ƒc is compatible with altered synchronization of SMUs during sleep. We speculate that these changes may contribute to the failure of dilator muscles to improve flow limitation during sleep in older subjects.

Original languageEnglish (US)
Pages (from-to)53-57
Number of pages5
JournalRespiratory Physiology and Neurobiology
Volume260
DOIs
StatePublished - Feb 1 2019

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Pharyngeal Muscles
Healthy Volunteers
Sleep
Muscles
Wakefulness
Ataxia
Arousal

Keywords

  • Centroid frequency
  • Genioglossus
  • Obstructive sleep apnea
  • Spectral analysis
  • Upper airway

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Spectral analysis of peri-pharyngeal muscles’ EMG in patients with OSA and healthy subjects. / Oliven, Ron; Cohen, Guy; Somri, Mostafa; Schwartz, Alan R; Oliven, Arie.

In: Respiratory Physiology and Neurobiology, Vol. 260, 01.02.2019, p. 53-57.

Research output: Contribution to journalArticle

Oliven, Ron ; Cohen, Guy ; Somri, Mostafa ; Schwartz, Alan R ; Oliven, Arie. / Spectral analysis of peri-pharyngeal muscles’ EMG in patients with OSA and healthy subjects. In: Respiratory Physiology and Neurobiology. 2019 ; Vol. 260. pp. 53-57.
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