Specificity of the innate immune system: A closer look at the mosquito pattern-recognition receptor repertoire

Suchismita Das, Yuemei Dong, Lindsey Garver, George Dimopoulos

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The insect innate immune system is encoded by three major functional categories of genes that are involved in (1) recognition of invading microbes; (2) immune-signal amplification and transduction; and (3) effector mechanisms that mediate the killing and clearance of infectious microorganisms. Despite its lack of adaptive immune mechanisms and antibodymediated defences similar to those found in vertebrates, the innate immune system in insects is quite specific in its antimicrobial action. Once invading microbes are recognized through specific interaction between patternrecognition receptors (PRRs) and pathogen-associated molecular patterns (PAMPs), a variety of defence reactions can be activated. This chapter discusses the specificity of the innate immune responses at the level of PRRs, with a major focus on the mosquito Anopheles gambiae as a model system. It first provides a general overview of the insects' PRR repertoire and highlights some of its most interesting features with regard to antimicrobial defence. It then provides detailed molecular and functional descriptions of some of the best characterized PRR families.

Original languageEnglish (US)
Title of host publicationInsect Infection and Immunity
Subtitle of host publicationEvolution, Ecology, and Mechanisms
PublisherOxford University Press
ISBN (Electronic)9780191720505
ISBN (Print)9780199551354
DOIs
StatePublished - Sep 1 2009

Keywords

  • Antimicrobial defence
  • Immune response
  • Insect immunity
  • Mosquitoes
  • Pathogen-associated molecular patterns

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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