Specificity of muscle reinnervation after epineurial and individual fascicular suture of the rat sciatic nerve

Thomas Brushart, E. C. Tarlow, M. M. Mesulam

Research output: Contribution to journalArticle

Abstract

We experimentally analyzed the specificity of muscle reinnervation after suture and regeneration of rat sciatic nerve. We used a horseradish peroxidase (HRP) technique of axon tracing to compare the number and location of motoneurons that innervate muscle via the peroneal nerve after epineurial and individual fascicular suture of the parent sciatic nerve. These motoneurons are significantly reduced in number from control levels and are often in spinal cord locations that indicate previous innervation of antagonistic muscle via the tibial nerve. This inappropriate reinnervation of peroneal muscle by tibial motoneurons is minimized by individual fascicular suture without compromise of overall reinnervation. Our findings thus support the hypothesis that individual fascicular suture may avoid distortion of the central connections of peripheral units.

Original languageEnglish (US)
Pages (from-to)248-253
Number of pages6
JournalJournal of Hand Surgery
Volume8
Issue number3
StatePublished - 1983
Externally publishedYes

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Sciatic Nerve
Sutures
Motor Neurons
Muscles
Tibial Nerve
Peroneal Nerve
Horseradish Peroxidase
Axons
Regeneration
Spinal Cord

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

Specificity of muscle reinnervation after epineurial and individual fascicular suture of the rat sciatic nerve. / Brushart, Thomas; Tarlow, E. C.; Mesulam, M. M.

In: Journal of Hand Surgery, Vol. 8, No. 3, 1983, p. 248-253.

Research output: Contribution to journalArticle

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