Specificity of genetic biomarker studies in cancer research: A systematic review

Garrett Green; Ruben Carmona; Kaveh Zakeri; Chih Han Lee; Saif Borgan; Zaid Marhoon; Andrew Sharabi; Loren K. Mell

doi:10.1371/journal.pone.0156489

Specificity of genetic biomarker studies in cancer research: A systematic review

Garrett Green, Ruben Carmona, Kaveh Zakeri, Chih Han Lee, Saif Borgan, Zaid Marhoon, Andrew Sharabi, Loren K. Mell

School of Medicine

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

As genetic information becomes more readily available, there is increasing demand from both patients and providers to develop personalized approaches to cancer care. Investigators are increasingly reporting numbers of studies correlating genomic signatures and other biomarkers to survival endpoints. The extent to which cancer-specific and non-specific effects are reported in contemporary studies is unknown. In this review of 85 high-impact studies associating genetic biomarkers with cancer outcomes, 95% reported significant associations with event-free survival outcomes, yet less than half reported effects on a cancer-specific endpoint. This methodology leaves open the possibility that observed associations are unrelated to cancer.

Original language	English (US)
Article number	e0156489
Journal	PloS one
Volume	11
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0156489
State	Published - Jul 1 2016

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences
General

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abstract = "As genetic information becomes more readily available, there is increasing demand from both patients and providers to develop personalized approaches to cancer care. Investigators are increasingly reporting numbers of studies correlating genomic signatures and other biomarkers to survival endpoints. The extent to which cancer-specific and non-specific effects are reported in contemporary studies is unknown. In this review of 85 high-impact studies associating genetic biomarkers with cancer outcomes, 95% reported significant associations with event-free survival outcomes, yet less than half reported effects on a cancer-specific endpoint. This methodology leaves open the possibility that observed associations are unrelated to cancer.",

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AU - Zakeri, Kaveh

AU - Lee, Chih Han

AU - Borgan, Saif

AU - Marhoon, Zaid

AU - Sharabi, Andrew

AU - Mell, Loren K.

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Specificity of genetic biomarker studies in cancer research: A systematic review

Abstract

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