Specification of excitatory neurons in the developing cerebral cortex: Progenitor diversity and environmental influences

Marcos R. Costa, Ulrich Mueller

Research output: Contribution to journalReview article

Abstract

The mature cerebral cortex harbors a heterogeneous population of glutamatergic neurons, organized into a highly intricate histological architecture. Classically, this mixed population of neurons was thought to be generated sequentially from a seemingly homogenous group of progenitors under the influence of external cues. This view, however, has been challenged in the last decade by evidences pointing to the existence of fate-restricted neuronal progenitors in the developing neocortex. Here, we review classical studies using cell transplantation, retroviral labeling and cell culture, as well as new data from genetic fate-mapping analysis, to discuss the lineage relationships between neocortical progenitors and subclasses of excitatory neurons. We also propose a temporal model to conciliate the existence of fate-restricted progenitors alongside multipotent progenitors in the neocortex. Finally, we discuss evidences for a critical period of plasticity among post mitotic excitatory cortical neurons when environmental influences could change neuronal cell fate.

Original languageEnglish (US)
Article number449
Pages (from-to)1-9
Number of pages9
JournalFrontiers in Cellular Neuroscience
Volume8
Issue numberJAN
DOIs
StatePublished - Jan 12 2015
Externally publishedYes

Fingerprint

Cerebral Cortex
Neurons
Neocortex
Cell Transplantation
Population
Cues
Cell Culture Techniques

Keywords

  • Cerebral cortex
  • Development
  • Excitatory neurons
  • Neuronal specification
  • Progenitor diversity

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Specification of excitatory neurons in the developing cerebral cortex : Progenitor diversity and environmental influences. / Costa, Marcos R.; Mueller, Ulrich.

In: Frontiers in Cellular Neuroscience, Vol. 8, No. JAN, 449, 12.01.2015, p. 1-9.

Research output: Contribution to journalReview article

@article{7369ded63fdc4eef904447b2bd7aba3f,
title = "Specification of excitatory neurons in the developing cerebral cortex: Progenitor diversity and environmental influences",
abstract = "The mature cerebral cortex harbors a heterogeneous population of glutamatergic neurons, organized into a highly intricate histological architecture. Classically, this mixed population of neurons was thought to be generated sequentially from a seemingly homogenous group of progenitors under the influence of external cues. This view, however, has been challenged in the last decade by evidences pointing to the existence of fate-restricted neuronal progenitors in the developing neocortex. Here, we review classical studies using cell transplantation, retroviral labeling and cell culture, as well as new data from genetic fate-mapping analysis, to discuss the lineage relationships between neocortical progenitors and subclasses of excitatory neurons. We also propose a temporal model to conciliate the existence of fate-restricted progenitors alongside multipotent progenitors in the neocortex. Finally, we discuss evidences for a critical period of plasticity among post mitotic excitatory cortical neurons when environmental influences could change neuronal cell fate.",
keywords = "Cerebral cortex, Development, Excitatory neurons, Neuronal specification, Progenitor diversity",
author = "Costa, {Marcos R.} and Ulrich Mueller",
year = "2015",
month = "1",
day = "12",
doi = "10.3389/fncel.2014.00449",
language = "English (US)",
volume = "8",
pages = "1--9",
journal = "Frontiers in Cellular Neuroscience",
issn = "1662-5102",
publisher = "Frontiers Research Foundation",
number = "JAN",

}

TY - JOUR

T1 - Specification of excitatory neurons in the developing cerebral cortex

T2 - Progenitor diversity and environmental influences

AU - Costa, Marcos R.

AU - Mueller, Ulrich

PY - 2015/1/12

Y1 - 2015/1/12

N2 - The mature cerebral cortex harbors a heterogeneous population of glutamatergic neurons, organized into a highly intricate histological architecture. Classically, this mixed population of neurons was thought to be generated sequentially from a seemingly homogenous group of progenitors under the influence of external cues. This view, however, has been challenged in the last decade by evidences pointing to the existence of fate-restricted neuronal progenitors in the developing neocortex. Here, we review classical studies using cell transplantation, retroviral labeling and cell culture, as well as new data from genetic fate-mapping analysis, to discuss the lineage relationships between neocortical progenitors and subclasses of excitatory neurons. We also propose a temporal model to conciliate the existence of fate-restricted progenitors alongside multipotent progenitors in the neocortex. Finally, we discuss evidences for a critical period of plasticity among post mitotic excitatory cortical neurons when environmental influences could change neuronal cell fate.

AB - The mature cerebral cortex harbors a heterogeneous population of glutamatergic neurons, organized into a highly intricate histological architecture. Classically, this mixed population of neurons was thought to be generated sequentially from a seemingly homogenous group of progenitors under the influence of external cues. This view, however, has been challenged in the last decade by evidences pointing to the existence of fate-restricted neuronal progenitors in the developing neocortex. Here, we review classical studies using cell transplantation, retroviral labeling and cell culture, as well as new data from genetic fate-mapping analysis, to discuss the lineage relationships between neocortical progenitors and subclasses of excitatory neurons. We also propose a temporal model to conciliate the existence of fate-restricted progenitors alongside multipotent progenitors in the neocortex. Finally, we discuss evidences for a critical period of plasticity among post mitotic excitatory cortical neurons when environmental influences could change neuronal cell fate.

KW - Cerebral cortex

KW - Development

KW - Excitatory neurons

KW - Neuronal specification

KW - Progenitor diversity

UR - http://www.scopus.com/inward/record.url?scp=84920952632&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920952632&partnerID=8YFLogxK

U2 - 10.3389/fncel.2014.00449

DO - 10.3389/fncel.2014.00449

M3 - Review article

C2 - 25628534

AN - SCOPUS:84920952632

VL - 8

SP - 1

EP - 9

JO - Frontiers in Cellular Neuroscience

JF - Frontiers in Cellular Neuroscience

SN - 1662-5102

IS - JAN

M1 - 449

ER -