Specific metaphase and interphase detection of the breakpoint region in 8q24 of Burkitt lymphoma cells by triple-color fluorescence in situ hybridization

T. Ried, C. Lengauer, T. Cremer, J. Wiegant, A. K. Raap, M. Van der Ploeg, P. Groitl, M. Lipp

Research output: Contribution to journalArticlepeer-review

Abstract

Triple fluorescence in situ hybridization with a plasmid DNA library from sorted human chromosomes 8 in combination with bacteriophage clones flanking the breakpoint in 8q24 of the Burkitt lymphoma cell line J1 was used for the specific delineation of this breakpoint in individual tumor cells. With this approach, tumor-specific breakpoints in translocation chromosomes can be detected at all stages of the cell cycle with high specificity.

Original languageEnglish (US)
Pages (from-to)69-74
Number of pages6
JournalGenes Chromosomes and Cancer
Volume4
Issue number1
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

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