Specific in vitro initiation of transcription on conalbumin and ovalbumin genes and comparison with adenovirus-2 early and late genes

B. Wasylyk, C. Kédinger, J. Corden, O. Brison, P. Chambon

Research output: Contribution to journalArticlepeer-review

Abstract

Specific initiation of transcription of cloned conalbumin and ovalbumin genes has been obtained in a cell-free system in the presence of purified calf thymus RNA polymerase B. Comparison with the adenovirus-2 early (E1 A) and major late genes reveals marked variations in transcriptional efficiencies. Specific fragmentation of the conalbumin gene DNA indicates that a short DNA segment 5′ to the initiation site is involved in specific transcription.

Original languageEnglish (US)
Pages (from-to)367-373
Number of pages7
JournalNature
Volume285
Issue number5764
DOIs
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • General

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