Specific chromosomal abnormalities in malignant human gliomas

S. H. Bigner, J. Mark, P. C. Burger, M. S. Mahaley, D. E. Bullard, L. H. Muhlbaier, D. D. Bigner

Research output: Contribution to journalArticle

Abstract

Karyotypic analysis of 54 malignant human gliomas (5 anaplastic astrocytomas, 43 glioblastoma multiformes, 3 gliosarcomas, 2 giant cell glioblastomas, 1 anaplastic mixed glioma) has demonstrated that 12 tumors contained normal stemlines or only lacked one sex chromosome. The 42 tumors with abnormal karyotypes included 38 tumors which could be completely analyzed. Six of these 38 cases had near-triploid or near-tetraploid stemlines and 32 had near-diploid stemlines. Statistically significant numerical deviations in the near-diploid group were gains of chromosome 7 (26 of 32; P <0.001), and losses of chromosome 10 (19 of 32; P <0.001). Double minutes occurred in 18 of 32 near diploid tumors. The distribution of structural abnormalities was analyzed statistically by comparing the incidence of breakpoints in each chromosomal arm to the expected value based on chromosomal arm length. This analysis demonstrated that structural abnormalities of 9p and 19q were significant statistically (P <0.005 and P = 0.02, respectively). Although chromosome 1, 6p, the centrometric region of chromosome 11, 13q, and 15q were also frequently involved in structural abnormalities, the incidence of these breaks did not reach statistical significance. This demonstration of specific chromosomal abnormalities in near-diploid gliomas provides the basis for the investigation of genes which may be quantitatively or qualitatively altered in these neoplasms.

Original languageEnglish (US)
Pages (from-to)405-411
Number of pages7
JournalCancer Research
Volume48
Issue number2
StatePublished - 1988
Externally publishedYes

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Glioma
Chromosome Aberrations
Diploidy
Neoplasms
Glioblastoma
Gliosarcoma
Abnormal Karyotype
Chromosomes, Human, Pair 19
Triploidy
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 11
Sex Chromosomes
Chromosomes, Human, Pair 7
Tetraploidy
Chromosomes, Human, Pair 1
Incidence
Astrocytoma
Genes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Bigner, S. H., Mark, J., Burger, P. C., Mahaley, M. S., Bullard, D. E., Muhlbaier, L. H., & Bigner, D. D. (1988). Specific chromosomal abnormalities in malignant human gliomas. Cancer Research, 48(2), 405-411.

Specific chromosomal abnormalities in malignant human gliomas. / Bigner, S. H.; Mark, J.; Burger, P. C.; Mahaley, M. S.; Bullard, D. E.; Muhlbaier, L. H.; Bigner, D. D.

In: Cancer Research, Vol. 48, No. 2, 1988, p. 405-411.

Research output: Contribution to journalArticle

Bigner, SH, Mark, J, Burger, PC, Mahaley, MS, Bullard, DE, Muhlbaier, LH & Bigner, DD 1988, 'Specific chromosomal abnormalities in malignant human gliomas', Cancer Research, vol. 48, no. 2, pp. 405-411.
Bigner SH, Mark J, Burger PC, Mahaley MS, Bullard DE, Muhlbaier LH et al. Specific chromosomal abnormalities in malignant human gliomas. Cancer Research. 1988;48(2):405-411.
Bigner, S. H. ; Mark, J. ; Burger, P. C. ; Mahaley, M. S. ; Bullard, D. E. ; Muhlbaier, L. H. ; Bigner, D. D. / Specific chromosomal abnormalities in malignant human gliomas. In: Cancer Research. 1988 ; Vol. 48, No. 2. pp. 405-411.
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