Specific cellular stimulation in the primary immune response: Experimental test of a quantized model

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Abstract

Dose-response and dose-suppression curves have been measured for the primary immune response in mice, in vivo and in vitro, by using size-fractionated linear polymers of acrylamide substituted with hapten. The results are in general agreement with a simple theory based on the premise that the specific primary immunological response is quantized at some fundamental and limiting step, requiring a minimum number of linked antigen receptors for response.

Original languageEnglish (US)
Pages (from-to)884-888
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume79
Issue number3 I
DOIs
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • General

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