TY - JOUR
T1 - Specific cellular stimulation in the primary immune response
T2 - Experimental test of a quantized model
AU - Dintzis, Renee Z
AU - Vogelstein, B.
AU - Dintzis, H. M.
PY - 1982
Y1 - 1982
N2 - Dose-response and dose-suppression curves have been measured for the primary immune response in mice, in vivo and in vitro, by using size-fractionated linear polymers of acrylamide substituted with hapten. The results are in general agreement with a simple theory based on the premise that the specific primary immunological response is quantized at some fundamental and limiting step, requiring a minimum number of linked antigen receptors for response.
AB - Dose-response and dose-suppression curves have been measured for the primary immune response in mice, in vivo and in vitro, by using size-fractionated linear polymers of acrylamide substituted with hapten. The results are in general agreement with a simple theory based on the premise that the specific primary immunological response is quantized at some fundamental and limiting step, requiring a minimum number of linked antigen receptors for response.
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U2 - 10.1073/pnas.79.3.884
DO - 10.1073/pnas.79.3.884
M3 - Article
C2 - 6950432
AN - SCOPUS:0020071393
SN - 0027-8424
VL - 79
SP - 884
EP - 888
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 3 I
ER -