TY - JOUR
T1 - Specific antibody to Cryptococcus neoformans alters human leukocyte cytokine synthesis and promotes T-cell proliferation
AU - Vecchiarelli, Anna
AU - Retini, Cinzia
AU - Monari, Claudia
AU - Casadevall, Arturo
PY - 1998/3
Y1 - 1998/3
N2 - Addition of a monoclonal antibody which binds the Cryptococcus neoformans capsule to suspensions of human monocytes, T lymphocytes, and cryptococcal cells (i) enhances interleukin-1β (IL-1β), tumor necrosis factor alpha, and IL-2 production; (ii) reduces IL-10 secretion; and (iii) promotes T-cell proliferation. The ability of specific antibody to influence cytokine production and lymphoproliferation suggests a mechanism by which humoral immunity can influence cell-mediated immunity.
AB - Addition of a monoclonal antibody which binds the Cryptococcus neoformans capsule to suspensions of human monocytes, T lymphocytes, and cryptococcal cells (i) enhances interleukin-1β (IL-1β), tumor necrosis factor alpha, and IL-2 production; (ii) reduces IL-10 secretion; and (iii) promotes T-cell proliferation. The ability of specific antibody to influence cytokine production and lymphoproliferation suggests a mechanism by which humoral immunity can influence cell-mediated immunity.
UR - http://www.scopus.com/inward/record.url?scp=0031936352&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031936352&partnerID=8YFLogxK
U2 - 10.1128/iai.66.3.1244-1247.1998
DO - 10.1128/iai.66.3.1244-1247.1998
M3 - Article
C2 - 9488420
AN - SCOPUS:0031936352
VL - 66
SP - 1244
EP - 1247
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 3
ER -