Specific antibody to Cryptococcus neoformans alters human leukocyte cytokine synthesis and promotes T-cell proliferation

Anna Vecchiarelli, Cinzia Retini, Claudia Monari, Arturo Casadevall

Research output: Contribution to journalArticlepeer-review

Abstract

Addition of a monoclonal antibody which binds the Cryptococcus neoformans capsule to suspensions of human monocytes, T lymphocytes, and cryptococcal cells (i) enhances interleukin-1β (IL-1β), tumor necrosis factor alpha, and IL-2 production; (ii) reduces IL-10 secretion; and (iii) promotes T-cell proliferation. The ability of specific antibody to influence cytokine production and lymphoproliferation suggests a mechanism by which humoral immunity can influence cell-mediated immunity.

Original languageEnglish (US)
Pages (from-to)1244-1247
Number of pages4
JournalInfection and immunity
Volume66
Issue number3
DOIs
StatePublished - Mar 1998
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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