Specific antibody to Cryptococcus neoformans alters human leukocyte cytokine synthesis and promotes T-cell proliferation

Anna Vecchiarelli; Cinzia Retini; Claudia Monari; Arturo Casadevall

doi:10.1128/iai.66.3.1244-1247.1998

Specific antibody to Cryptococcus neoformans alters human leukocyte cytokine synthesis and promotes T-cell proliferation

Anna Vecchiarelli, Cinzia Retini, Claudia Monari, Arturo Casadevall

Research output: Contribution to journal › Article › peer-review

Abstract

Addition of a monoclonal antibody which binds the Cryptococcus neoformans capsule to suspensions of human monocytes, T lymphocytes, and cryptococcal cells (i) enhances interleukin-1β (IL-1β), tumor necrosis factor alpha, and IL-2 production; (ii) reduces IL-10 secretion; and (iii) promotes T-cell proliferation. The ability of specific antibody to influence cytokine production and lymphoproliferation suggests a mechanism by which humoral immunity can influence cell-mediated immunity.

Original language	English (US)
Pages (from-to)	1244-1247
Number of pages	4
Journal	Infection and immunity
Volume	66
Issue number	3
DOIs	https://doi.org/10.1128/iai.66.3.1244-1247.1998
State	Published - Mar 1998
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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abstract = "Addition of a monoclonal antibody which binds the Cryptococcus neoformans capsule to suspensions of human monocytes, T lymphocytes, and cryptococcal cells (i) enhances interleukin-1β (IL-1β), tumor necrosis factor alpha, and IL-2 production; (ii) reduces IL-10 secretion; and (iii) promotes T-cell proliferation. The ability of specific antibody to influence cytokine production and lymphoproliferation suggests a mechanism by which humoral immunity can influence cell-mediated immunity.",

author = "Anna Vecchiarelli and Cinzia Retini and Claudia Monari and Arturo Casadevall",

year = "1998",

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AU - Monari, Claudia

AU - Casadevall, Arturo

PY - 1998/3

Y1 - 1998/3

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AB - Addition of a monoclonal antibody which binds the Cryptococcus neoformans capsule to suspensions of human monocytes, T lymphocytes, and cryptococcal cells (i) enhances interleukin-1β (IL-1β), tumor necrosis factor alpha, and IL-2 production; (ii) reduces IL-10 secretion; and (iii) promotes T-cell proliferation. The ability of specific antibody to influence cytokine production and lymphoproliferation suggests a mechanism by which humoral immunity can influence cell-mediated immunity.

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Specific antibody to Cryptococcus neoformans alters human leukocyte cytokine synthesis and promotes T-cell proliferation

Abstract

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