Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors.

S. Dandekar; S. Sukumar; H. Zarbl; L. J. Young; R. D. Cardiff

doi:10.1128/MCB.6.11.4104

Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors.

S. Dandekar, S. Sukumar, H. Zarbl, L. J. Young, R. D. Cardiff

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

Genomic DNAs from dimethylbenzanthracene-induced BALB/c mouse mammary tumors arising from the transplantable hyperplastic outgrowth (HPO) line designated DI/UCD transformed NIH 3T3 cells upon transfection. Transforming activity was attributed to the presence of activated Harvey ras-1 oncogenes containing an A----T transversion at the middle adenosine nucleotide in codon 61. DNAs from untreated DI/UCD HPO cells and radiation-induced and spontaneous mammary tumors from the DI/UCD HPO line failed to transform NIH 3T3 cells. The results indicated that the mutation activation of Harvey ras-1 oncogenes was specific to dimethylbenzanthracene treatment in the mouse mammary tumor system.

Original language	English (US)
Pages (from-to)	4104-4108
Number of pages	5
Journal	Molecular and cellular biology
Volume	6
Issue number	11
DOIs	https://doi.org/10.1128/MCB.6.11.4104
State	Published - Nov 1986
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Cell Biology

Access to Document

10.1128/MCB.6.11.4104

Cite this

@article{e3d643f3b9124581a89365be0b39df08,

title = "Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors.",

abstract = "Genomic DNAs from dimethylbenzanthracene-induced BALB/c mouse mammary tumors arising from the transplantable hyperplastic outgrowth (HPO) line designated DI/UCD transformed NIH 3T3 cells upon transfection. Transforming activity was attributed to the presence of activated Harvey ras-1 oncogenes containing an A----T transversion at the middle adenosine nucleotide in codon 61. DNAs from untreated DI/UCD HPO cells and radiation-induced and spontaneous mammary tumors from the DI/UCD HPO line failed to transform NIH 3T3 cells. The results indicated that the mutation activation of Harvey ras-1 oncogenes was specific to dimethylbenzanthracene treatment in the mouse mammary tumor system.",

author = "S. Dandekar and S. Sukumar and H. Zarbl and Young, {L. J.} and Cardiff, {R. D.}",

year = "1986",

month = nov,

doi = "10.1128/MCB.6.11.4104",

language = "English (US)",

volume = "6",

pages = "4104--4108",

journal = "Molecular and cellular biology",

issn = "0270-7306",

publisher = "American Society for Microbiology",

number = "11",

}

TY - JOUR

T1 - Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors.

AU - Dandekar, S.

AU - Sukumar, S.

AU - Zarbl, H.

AU - Young, L. J.

AU - Cardiff, R. D.

PY - 1986/11

Y1 - 1986/11

N2 - Genomic DNAs from dimethylbenzanthracene-induced BALB/c mouse mammary tumors arising from the transplantable hyperplastic outgrowth (HPO) line designated DI/UCD transformed NIH 3T3 cells upon transfection. Transforming activity was attributed to the presence of activated Harvey ras-1 oncogenes containing an A----T transversion at the middle adenosine nucleotide in codon 61. DNAs from untreated DI/UCD HPO cells and radiation-induced and spontaneous mammary tumors from the DI/UCD HPO line failed to transform NIH 3T3 cells. The results indicated that the mutation activation of Harvey ras-1 oncogenes was specific to dimethylbenzanthracene treatment in the mouse mammary tumor system.

AB - Genomic DNAs from dimethylbenzanthracene-induced BALB/c mouse mammary tumors arising from the transplantable hyperplastic outgrowth (HPO) line designated DI/UCD transformed NIH 3T3 cells upon transfection. Transforming activity was attributed to the presence of activated Harvey ras-1 oncogenes containing an A----T transversion at the middle adenosine nucleotide in codon 61. DNAs from untreated DI/UCD HPO cells and radiation-induced and spontaneous mammary tumors from the DI/UCD HPO line failed to transform NIH 3T3 cells. The results indicated that the mutation activation of Harvey ras-1 oncogenes was specific to dimethylbenzanthracene treatment in the mouse mammary tumor system.

UR - http://www.scopus.com/inward/record.url?scp=0022815366&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022815366&partnerID=8YFLogxK

U2 - 10.1128/MCB.6.11.4104

DO - 10.1128/MCB.6.11.4104

M3 - Article

C2 - 3099168

AN - SCOPUS:0022815366

SN - 0270-7306

VL - 6

SP - 4104

EP - 4108

JO - Molecular and cellular biology

JF - Molecular and cellular biology

IS - 11

ER -

Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors.

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this