Species- and genus-specific antigenic determinants of simian agent 12 VP1 as defined with monoclonal antibodies

Charles V. Benton, Raymond V. Gilden, Keerti V. Shah

Research output: Contribution to journalArticlepeer-review

Abstract

Monoclonal antibodies were developed against the baboon papovavirus simian agent 12 (SA12). Both SA12-specific and simian virus 40-polyoma Papovaviridae genus-reactive monoclones were isolated. Immunoprecipitation and SDS-PAGE of [35S]methionine-labeled SA12 revealed that all monoclonal antibodies, whether SA12 specific or reactive throughout the genus, were directed against the major capsid protein, VP1, thus directly confirming antigenic polymorphism in this polypeptide.

Original languageEnglish (US)
Pages (from-to)490-495
Number of pages6
JournalVirology
Volume117
Issue number2
DOIs
StatePublished - Mar 1982

ASJC Scopus subject areas

  • Virology

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