Specialized fatty acid synthesis in African trypanosomes: Myristate for GPI anchors

Yasu S. Morita, Kimberly S. Paul, Paul T. Englund

Research output: Contribution to journalArticle

Abstract

African trypanosomes, the cause of sleeping sickness, need massive amounts of myristate to remodel glycosyl phosphatidylinositol (GPI) anchors on their surface glycoproteins. However, it has been believed that the parasite is unable to synthesize any fatty acids, and myristate is not abundant in the hosts' bloodstreams. Thus, it has been unclear how trypanosomes meet their myristate requirement. Here we found that they could indeed synthesize fatty acids. The synthetic pathway was unique in that the major product, myristate, was preferentially incorporated into GPIs and not into other lipids. The antibiotic thiolactomycin inhibited myristate synthesis and killed the parasite, making this pathway a potential chemotherapeutic target.

Original languageEnglish (US)
Pages (from-to)140-143
Number of pages4
JournalScience
Volume288
Issue number5463
DOIs
StatePublished - Apr 7 2000

ASJC Scopus subject areas

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