Introduction Cerebral cavernous malformations (CCM) of the nervous system are relatively rare and can be symptomatic or incidentally discovered. Factors leading to their discovery are varied and not always causally associated. While a seizure may lead to discovery of a symptomatic CCM, a headache may lead to an incidental discovery of an asymptomatic CCM. Cerebrovascular neurologists and neurosurgeons are often asked about the safety and relationship of various medical issues with the CCM. The problem of epilepsy is covered in another chapter. In this chapter, we focus on some common questions that have arisen during consultation, such as the relationship to migraine, effects of pregnancy, and particularly the safety of use of antithrombotic agents in CCM patients. With the widespread use of brain MRI and the more frequent use of hemosiderin-sensitive sequences, the discovery of asymptomatic CCMs will probably increase. This book contains current information concerning the pathology, diagnosis and natural history and treatment of CCMs, but a number of medical and neurological issues arise in patients with CCMs that have not been as well studied. These issues will eventually present to the practitioner, and we have reviewed the literature to give the best guidance on management.
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