Spatiotemporal and frequency domain analysis of auditory paired stimuli processing in schizophrenia and bipolar disorder with psychosis

Jordan P. Hamm, Lauren E. Ethridge, John R. Shapiro, Michael C. Stevens, Nashaat N. Boutros, Ann T. Summerfelt, Matcheri S. Keshavan, John A. Sweeney, Godfrey Pearlson, Carol A. Tamminga, Gunvant Thaker, Brett A. Clementz

Research output: Contribution to journalArticle

Abstract

Individuals with schizophrenia (SZ) or bipolar disorder with psychosis (BPP) may share neurophysiological abnormalities as measured in auditory paired-stimuli paradigms with electroencephalography (EEG). Such investigations have been limited, however, by quantifying only event-related potential peaks and/or broad frequency bands at limited scalp locations without considering possible mediating factors (e.g., baseline differences). Results from 64-sensor EEG collected in 180 age- and gender-matched participants reveal (i) accentuated prestimulus gamma oscillations and (ii) reduced P2 amplitudes and theta/alpha oscillations to S1 among participants with both SZ and BPP. Conversely, (iii) N1s in those with SZ to S1 were reduced compared to healthy volunteers and those with BPP, whereas (iv) beta range oscillations 200-300ms following S2 were accentuated in those with BPP but not those with SZ. Results reveal a pattern of both unique and shared neurophysiological phenotypes occurring within major psychotic diagnoses.

Original languageEnglish (US)
Pages (from-to)522-530
Number of pages9
JournalPsychophysiology
Volume49
Issue number4
DOIs
StatePublished - Apr 2012
Externally publishedYes

Fingerprint

Bipolar Disorder
Psychotic Disorders
Schizophrenia
Electroencephalography
Scalp
Evoked Potentials
Healthy Volunteers
Phenotype
Auditory Stimuli
Psychosis
Oscillation

Keywords

  • EEG/ERP
  • Psychopathological
  • Sensation/perception

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Experimental and Cognitive Psychology
  • Neuropsychology and Physiological Psychology
  • Arts and Humanities (miscellaneous)
  • Developmental and Educational Psychology

Cite this

Hamm, J. P., Ethridge, L. E., Shapiro, J. R., Stevens, M. C., Boutros, N. N., Summerfelt, A. T., ... Clementz, B. A. (2012). Spatiotemporal and frequency domain analysis of auditory paired stimuli processing in schizophrenia and bipolar disorder with psychosis. Psychophysiology, 49(4), 522-530. https://doi.org/10.1111/j.1469-8986.2011.01327.x

Spatiotemporal and frequency domain analysis of auditory paired stimuli processing in schizophrenia and bipolar disorder with psychosis. / Hamm, Jordan P.; Ethridge, Lauren E.; Shapiro, John R.; Stevens, Michael C.; Boutros, Nashaat N.; Summerfelt, Ann T.; Keshavan, Matcheri S.; Sweeney, John A.; Pearlson, Godfrey; Tamminga, Carol A.; Thaker, Gunvant; Clementz, Brett A.

In: Psychophysiology, Vol. 49, No. 4, 04.2012, p. 522-530.

Research output: Contribution to journalArticle

Hamm, JP, Ethridge, LE, Shapiro, JR, Stevens, MC, Boutros, NN, Summerfelt, AT, Keshavan, MS, Sweeney, JA, Pearlson, G, Tamminga, CA, Thaker, G & Clementz, BA 2012, 'Spatiotemporal and frequency domain analysis of auditory paired stimuli processing in schizophrenia and bipolar disorder with psychosis', Psychophysiology, vol. 49, no. 4, pp. 522-530. https://doi.org/10.1111/j.1469-8986.2011.01327.x
Hamm, Jordan P. ; Ethridge, Lauren E. ; Shapiro, John R. ; Stevens, Michael C. ; Boutros, Nashaat N. ; Summerfelt, Ann T. ; Keshavan, Matcheri S. ; Sweeney, John A. ; Pearlson, Godfrey ; Tamminga, Carol A. ; Thaker, Gunvant ; Clementz, Brett A. / Spatiotemporal and frequency domain analysis of auditory paired stimuli processing in schizophrenia and bipolar disorder with psychosis. In: Psychophysiology. 2012 ; Vol. 49, No. 4. pp. 522-530.
@article{5a6a0882aea243eeb5c32d33e692692c,
title = "Spatiotemporal and frequency domain analysis of auditory paired stimuli processing in schizophrenia and bipolar disorder with psychosis",
abstract = "Individuals with schizophrenia (SZ) or bipolar disorder with psychosis (BPP) may share neurophysiological abnormalities as measured in auditory paired-stimuli paradigms with electroencephalography (EEG). Such investigations have been limited, however, by quantifying only event-related potential peaks and/or broad frequency bands at limited scalp locations without considering possible mediating factors (e.g., baseline differences). Results from 64-sensor EEG collected in 180 age- and gender-matched participants reveal (i) accentuated prestimulus gamma oscillations and (ii) reduced P2 amplitudes and theta/alpha oscillations to S1 among participants with both SZ and BPP. Conversely, (iii) N1s in those with SZ to S1 were reduced compared to healthy volunteers and those with BPP, whereas (iv) beta range oscillations 200-300ms following S2 were accentuated in those with BPP but not those with SZ. Results reveal a pattern of both unique and shared neurophysiological phenotypes occurring within major psychotic diagnoses.",
keywords = "EEG/ERP, Psychopathological, Sensation/perception",
author = "Hamm, {Jordan P.} and Ethridge, {Lauren E.} and Shapiro, {John R.} and Stevens, {Michael C.} and Boutros, {Nashaat N.} and Summerfelt, {Ann T.} and Keshavan, {Matcheri S.} and Sweeney, {John A.} and Godfrey Pearlson and Tamminga, {Carol A.} and Gunvant Thaker and Clementz, {Brett A.}",
year = "2012",
month = "4",
doi = "10.1111/j.1469-8986.2011.01327.x",
language = "English (US)",
volume = "49",
pages = "522--530",
journal = "Psychophysiology",
issn = "0048-5772",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Spatiotemporal and frequency domain analysis of auditory paired stimuli processing in schizophrenia and bipolar disorder with psychosis

AU - Hamm, Jordan P.

AU - Ethridge, Lauren E.

AU - Shapiro, John R.

AU - Stevens, Michael C.

AU - Boutros, Nashaat N.

AU - Summerfelt, Ann T.

AU - Keshavan, Matcheri S.

AU - Sweeney, John A.

AU - Pearlson, Godfrey

AU - Tamminga, Carol A.

AU - Thaker, Gunvant

AU - Clementz, Brett A.

PY - 2012/4

Y1 - 2012/4

N2 - Individuals with schizophrenia (SZ) or bipolar disorder with psychosis (BPP) may share neurophysiological abnormalities as measured in auditory paired-stimuli paradigms with electroencephalography (EEG). Such investigations have been limited, however, by quantifying only event-related potential peaks and/or broad frequency bands at limited scalp locations without considering possible mediating factors (e.g., baseline differences). Results from 64-sensor EEG collected in 180 age- and gender-matched participants reveal (i) accentuated prestimulus gamma oscillations and (ii) reduced P2 amplitudes and theta/alpha oscillations to S1 among participants with both SZ and BPP. Conversely, (iii) N1s in those with SZ to S1 were reduced compared to healthy volunteers and those with BPP, whereas (iv) beta range oscillations 200-300ms following S2 were accentuated in those with BPP but not those with SZ. Results reveal a pattern of both unique and shared neurophysiological phenotypes occurring within major psychotic diagnoses.

AB - Individuals with schizophrenia (SZ) or bipolar disorder with psychosis (BPP) may share neurophysiological abnormalities as measured in auditory paired-stimuli paradigms with electroencephalography (EEG). Such investigations have been limited, however, by quantifying only event-related potential peaks and/or broad frequency bands at limited scalp locations without considering possible mediating factors (e.g., baseline differences). Results from 64-sensor EEG collected in 180 age- and gender-matched participants reveal (i) accentuated prestimulus gamma oscillations and (ii) reduced P2 amplitudes and theta/alpha oscillations to S1 among participants with both SZ and BPP. Conversely, (iii) N1s in those with SZ to S1 were reduced compared to healthy volunteers and those with BPP, whereas (iv) beta range oscillations 200-300ms following S2 were accentuated in those with BPP but not those with SZ. Results reveal a pattern of both unique and shared neurophysiological phenotypes occurring within major psychotic diagnoses.

KW - EEG/ERP

KW - Psychopathological

KW - Sensation/perception

UR - http://www.scopus.com/inward/record.url?scp=84858704081&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858704081&partnerID=8YFLogxK

U2 - 10.1111/j.1469-8986.2011.01327.x

DO - 10.1111/j.1469-8986.2011.01327.x

M3 - Article

C2 - 22176721

AN - SCOPUS:84858704081

VL - 49

SP - 522

EP - 530

JO - Psychophysiology

JF - Psychophysiology

SN - 0048-5772

IS - 4

ER -