@article{2cbc0ba08e2045dab1c3ba4a854483f0,
title = "Spatially targeted screening to reduce tuberculosis transmission in high-incidence settings",
abstract = "As the leading infectious cause of death worldwide and the primary proximal cause of death in individuals living with HIV, tuberculosis remains a global concern. Existing tuberculosis control strategies that rely on passive case-finding appear insufficient to achieve targets for reductions in tuberculosis incidence and mortality. Active case-finding strategies aim to detect infectious individuals earlier in their infectious period to reduce onward transmission and improve treatment outcomes. Empirical studies of active case-finding have produced mixed results and determining how to direct active screening to those most at risk remains a topic of intense research. Our systematic review of literature evaluating the effects of geographically targeted tuberculosis screening interventions found three studies in low tuberculosis incidence settings, but none conducted in high tuberculosis incidence countries. We discuss open questions related to the use of spatially targeted approaches for active screening in countries where tuberculosis incidence is highest.",
author = "Cudahy, {Patrick G.T.} and Andrews, {Jason R.} and Alyssa Bilinski and Dowdy, {David W.} and Barun Mathema and Menzies, {Nicolas A.} and Salomon, {Joshua A.} and Sourya Shrestha and Ted Cohen",
note = "Funding Information: We thank Mark Gentry and Alexandria Brackett for their assistance with the literature search. This publication and workshop have been funded in whole or in part with Federal Funds from the Division of AIDS, National Institute of Allergy and Infectious Diseases, US National Institutes of Health (NIH), Department of Health and Human Services under contract number HHSN272201600001G Research Support Services for the Division of AIDS. Funding support was also provided in part by NIH grants R01AI112438 to TC , TW009338 and T32AI007517 to PGTC , and T32 AI007433 to AB. The South African Medical Research Council co-hosted the event. The Bill & Melinda Gates Foundation provided funding support for some participants to travel to the workshop. The sponsors of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. Funding Information: We thank Mark Gentry and Alexandria Brackett for their assistance with the literature search. This publication and workshop have been funded in whole or in part with Federal Funds from the Division of AIDS, National Institute of Allergy and Infectious Diseases, US National Institutes of Health (NIH), Department of Health and Human Services under contract number HHSN272201600001G Research Support Services for the Division of AIDS. Funding support was also provided in part by NIH grants R01AI112438 to TC, TW009338 and T32AI007517 to PGTC, and T32 AI007433 to AB. The South African Medical Research Council co-hosted the event. The Bill & Melinda Gates Foundation provided funding support for some participants to travel to the workshop. The sponsors of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2019",
month = mar,
doi = "10.1016/S1473-3099(18)30443-2",
language = "English (US)",
volume = "19",
pages = "e89--e95",
journal = "The Lancet Infectious Diseases",
issn = "1473-3099",
publisher = "Lancet Publishing Group",
number = "3",
}