Spatially resolved force spectroscopy of biological surfaces using the atomic force microscope

William F. Heinz, Jan H. Hoh

Research output: Contribution to journalArticle

Abstract

The spatial distribution of intermolecular forces governs macromolecular interactions. The atomic force microscope, a relatively new tool for investigating interaction forces between nanometer-scale objects, can be used to produce spatially resolved maps of the surface or material properties of a sample; these include charge density, adhesion and stiffness, as well as the force required to break specific ligand-receptor bonds. Maps such as these will provide fundamental insights into biological structure and will become an important tool for characterizing technologically important biological systems. Copyright (C) 1999 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)143-150
Number of pages8
JournalTrends in Biotechnology
Volume17
Issue number4
DOIs
StatePublished - Apr 1 1999

Fingerprint

Spectrum Analysis
Microscopes
Spectroscopy
Ligands
Biological systems
Charge density
Spatial distribution
Surface properties
Materials properties
Adhesion
Stiffness

ASJC Scopus subject areas

  • Bioengineering

Cite this

Spatially resolved force spectroscopy of biological surfaces using the atomic force microscope. / Heinz, William F.; Hoh, Jan H.

In: Trends in Biotechnology, Vol. 17, No. 4, 01.04.1999, p. 143-150.

Research output: Contribution to journalArticle

@article{7d84d04175aa4f6a958e1ce55b117510,
title = "Spatially resolved force spectroscopy of biological surfaces using the atomic force microscope",
abstract = "The spatial distribution of intermolecular forces governs macromolecular interactions. The atomic force microscope, a relatively new tool for investigating interaction forces between nanometer-scale objects, can be used to produce spatially resolved maps of the surface or material properties of a sample; these include charge density, adhesion and stiffness, as well as the force required to break specific ligand-receptor bonds. Maps such as these will provide fundamental insights into biological structure and will become an important tool for characterizing technologically important biological systems. Copyright (C) 1999 Elsevier Science Ltd.",
author = "Heinz, {William F.} and Hoh, {Jan H.}",
year = "1999",
month = "4",
day = "1",
doi = "10.1016/S0167-7799(99)01304-9",
language = "English (US)",
volume = "17",
pages = "143--150",
journal = "Trends in Biotechnology",
issn = "0167-7799",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Spatially resolved force spectroscopy of biological surfaces using the atomic force microscope

AU - Heinz, William F.

AU - Hoh, Jan H.

PY - 1999/4/1

Y1 - 1999/4/1

N2 - The spatial distribution of intermolecular forces governs macromolecular interactions. The atomic force microscope, a relatively new tool for investigating interaction forces between nanometer-scale objects, can be used to produce spatially resolved maps of the surface or material properties of a sample; these include charge density, adhesion and stiffness, as well as the force required to break specific ligand-receptor bonds. Maps such as these will provide fundamental insights into biological structure and will become an important tool for characterizing technologically important biological systems. Copyright (C) 1999 Elsevier Science Ltd.

AB - The spatial distribution of intermolecular forces governs macromolecular interactions. The atomic force microscope, a relatively new tool for investigating interaction forces between nanometer-scale objects, can be used to produce spatially resolved maps of the surface or material properties of a sample; these include charge density, adhesion and stiffness, as well as the force required to break specific ligand-receptor bonds. Maps such as these will provide fundamental insights into biological structure and will become an important tool for characterizing technologically important biological systems. Copyright (C) 1999 Elsevier Science Ltd.

UR - http://www.scopus.com/inward/record.url?scp=0033121032&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033121032&partnerID=8YFLogxK

U2 - 10.1016/S0167-7799(99)01304-9

DO - 10.1016/S0167-7799(99)01304-9

M3 - Article

C2 - 10203772

AN - SCOPUS:0033121032

VL - 17

SP - 143

EP - 150

JO - Trends in Biotechnology

JF - Trends in Biotechnology

SN - 0167-7799

IS - 4

ER -