Abstract
The spatial distribution of intermolecular forces governs macromolecular interactions. The atomic force microscope, a relatively new tool for investigating interaction forces between nanometer-scale objects, can be used to produce spatially resolved maps of the surface or material properties of a sample; these include charge density, adhesion and stiffness, as well as the force required to break specific ligand-receptor bonds. Maps such as these will provide fundamental insights into biological structure and will become an important tool for characterizing technologically important biological systems. Copyright (C) 1999 Elsevier Science Ltd.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 143-150 |
| Number of pages | 8 |
| Journal | Trends in Biotechnology |
| Volume | 17 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 1999 |
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ASJC Scopus subject areas
- Bioengineering
Cite this
Spatially resolved force spectroscopy of biological surfaces using the atomic force microscope. / Heinz, William F.; Hoh, Jan H.
In: Trends in Biotechnology, Vol. 17, No. 4, 01.04.1999, p. 143-150.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Spatially resolved force spectroscopy of biological surfaces using the atomic force microscope
AU - Heinz, William F.
AU - Hoh, Jan H.
PY - 1999/4/1
Y1 - 1999/4/1
N2 - The spatial distribution of intermolecular forces governs macromolecular interactions. The atomic force microscope, a relatively new tool for investigating interaction forces between nanometer-scale objects, can be used to produce spatially resolved maps of the surface or material properties of a sample; these include charge density, adhesion and stiffness, as well as the force required to break specific ligand-receptor bonds. Maps such as these will provide fundamental insights into biological structure and will become an important tool for characterizing technologically important biological systems. Copyright (C) 1999 Elsevier Science Ltd.
AB - The spatial distribution of intermolecular forces governs macromolecular interactions. The atomic force microscope, a relatively new tool for investigating interaction forces between nanometer-scale objects, can be used to produce spatially resolved maps of the surface or material properties of a sample; these include charge density, adhesion and stiffness, as well as the force required to break specific ligand-receptor bonds. Maps such as these will provide fundamental insights into biological structure and will become an important tool for characterizing technologically important biological systems. Copyright (C) 1999 Elsevier Science Ltd.
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UR - http://www.scopus.com/inward/citedby.url?scp=0033121032&partnerID=8YFLogxK
U2 - 10.1016/S0167-7799(99)01304-9
DO - 10.1016/S0167-7799(99)01304-9
M3 - Article
C2 - 10203772
AN - SCOPUS:0033121032
VL - 17
SP - 143
EP - 150
JO - Trends in Biotechnology
JF - Trends in Biotechnology
SN - 0167-7799
IS - 4
ER -