Spatially dissociated flow-metabolism coupling in brain activation

Manouchehr S. Vafaee, Albert Gjedde

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


The relationships among cerebral blood flow (CBF), oxygen consumption (CMRO2) and glucose use (CMRglc) constitute the basis of functional brain-imaging. Here we report spatially dissociated changes of CMRO2 and CBF during motor activity that lead us to propose a revision of conventional CBF-CMRO2 coupling models. In the left primary and supplementary motor cortices, CBF and CMRO2 rose significantly during finger-thumb tapping. However, in the right putamen CBF did not rise, despite a significant increase in CMRO2. We explain these observations by invoking a central command mechanism that regulates CBF in the putamen in anticipation of movement. By this mechanism, CBF rose in the putamen before the measurements of CBF and CMRO2 while CMRO 2 rose when actual motion commenced.

Original languageEnglish (US)
Pages (from-to)507-515
Number of pages9
Issue number2
StatePublished - Feb 2004


  • Brain activation
  • Flow-metabolism
  • Functional brain-imaging

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience


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