Spatially dissociated flow-metabolism coupling in brain activation

Manouchehr S. Vafaee; Albert Gjedde

doi:10.1016/j.neuroimage.2003.10.003

Spatially dissociated flow-metabolism coupling in brain activation

Manouchehr S. Vafaee, Albert Gjedde

School of Medicine

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

The relationships among cerebral blood flow (CBF), oxygen consumption (CMRO₂) and glucose use (CMR_glc) constitute the basis of functional brain-imaging. Here we report spatially dissociated changes of CMRO₂ and CBF during motor activity that lead us to propose a revision of conventional CBF-CMRO₂ coupling models. In the left primary and supplementary motor cortices, CBF and CMRO₂ rose significantly during finger-thumb tapping. However, in the right putamen CBF did not rise, despite a significant increase in CMRO₂. We explain these observations by invoking a central command mechanism that regulates CBF in the putamen in anticipation of movement. By this mechanism, CBF rose in the putamen before the measurements of CBF and CMRO₂ while CMRO ₂ rose when actual motion commenced.

Original language	English (US)
Pages (from-to)	507-515
Number of pages	9
Journal	NeuroImage
Volume	21
Issue number	2
DOIs	https://doi.org/10.1016/j.neuroimage.2003.10.003
State	Published - Feb 2004

Keywords

Brain activation
Flow-metabolism
Functional brain-imaging

ASJC Scopus subject areas

Neurology
Cognitive Neuroscience

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10.1016/j.neuroimage.2003.10.003

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title = "Spatially dissociated flow-metabolism coupling in brain activation",

abstract = "The relationships among cerebral blood flow (CBF), oxygen consumption (CMRO2) and glucose use (CMRglc) constitute the basis of functional brain-imaging. Here we report spatially dissociated changes of CMRO2 and CBF during motor activity that lead us to propose a revision of conventional CBF-CMRO2 coupling models. In the left primary and supplementary motor cortices, CBF and CMRO2 rose significantly during finger-thumb tapping. However, in the right putamen CBF did not rise, despite a significant increase in CMRO2. We explain these observations by invoking a central command mechanism that regulates CBF in the putamen in anticipation of movement. By this mechanism, CBF rose in the putamen before the measurements of CBF and CMRO2 while CMRO 2 rose when actual motion commenced.",

keywords = "Brain activation, Flow-metabolism, Functional brain-imaging",

author = "Vafaee, {Manouchehr S.} and Albert Gjedde",

note = "Funding Information: We thank Dr. Nicholas Gillings for his help in redesigning the gas-inhalation system, Jens Kristian Graverholt, Poul-Erik Nielsen and Dr. Soren B. Hansen for assistance with the automated blood sampling system, and the nuclear medicine technologists for assistance with PET experiments. This work was supported by Danish Medical Research Council grants 9305246, 9305247, 9601888 and 9802833, and Danish National Science Foundation Center of Excellence grant (CFIN, 2001).",

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doi = "10.1016/j.neuroimage.2003.10.003",

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AU - Vafaee, Manouchehr S.

AU - Gjedde, Albert

N1 - Funding Information: We thank Dr. Nicholas Gillings for his help in redesigning the gas-inhalation system, Jens Kristian Graverholt, Poul-Erik Nielsen and Dr. Soren B. Hansen for assistance with the automated blood sampling system, and the nuclear medicine technologists for assistance with PET experiments. This work was supported by Danish Medical Research Council grants 9305246, 9305247, 9601888 and 9802833, and Danish National Science Foundation Center of Excellence grant (CFIN, 2001).

PY - 2004/2

Y1 - 2004/2

N2 - The relationships among cerebral blood flow (CBF), oxygen consumption (CMRO2) and glucose use (CMRglc) constitute the basis of functional brain-imaging. Here we report spatially dissociated changes of CMRO2 and CBF during motor activity that lead us to propose a revision of conventional CBF-CMRO2 coupling models. In the left primary and supplementary motor cortices, CBF and CMRO2 rose significantly during finger-thumb tapping. However, in the right putamen CBF did not rise, despite a significant increase in CMRO2. We explain these observations by invoking a central command mechanism that regulates CBF in the putamen in anticipation of movement. By this mechanism, CBF rose in the putamen before the measurements of CBF and CMRO2 while CMRO 2 rose when actual motion commenced.

AB - The relationships among cerebral blood flow (CBF), oxygen consumption (CMRO2) and glucose use (CMRglc) constitute the basis of functional brain-imaging. Here we report spatially dissociated changes of CMRO2 and CBF during motor activity that lead us to propose a revision of conventional CBF-CMRO2 coupling models. In the left primary and supplementary motor cortices, CBF and CMRO2 rose significantly during finger-thumb tapping. However, in the right putamen CBF did not rise, despite a significant increase in CMRO2. We explain these observations by invoking a central command mechanism that regulates CBF in the putamen in anticipation of movement. By this mechanism, CBF rose in the putamen before the measurements of CBF and CMRO2 while CMRO 2 rose when actual motion commenced.

KW - Brain activation

KW - Flow-metabolism

KW - Functional brain-imaging

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JF - NeuroImage

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Spatially dissociated flow-metabolism coupling in brain activation

Abstract

Keywords

ASJC Scopus subject areas

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