Spatially adaptive multi-scale optimization for local parameter estimation in cardiac electrophysiology

Jwala Dhamala, Hermenegild J. Arevalo, John Sapp, Milan Horacek, Katherine C. Wu, Natalia A. Trayanova, Linwei Wang

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

To obtain a patient-specific cardiac electro-physiological (EP) model, it is important to estimate the 3-D distributed tissue properties of the myocardium. Ideally, the tissue property should be estimated at the resolution of the cardiac mesh. However, such high-dimensional estimation faces major challenges in identifiability and computation. Most existing works reduce this dimension by partitioning the cardiac mesh into a pre-defined set of segments. The resulting low-resolution solutions have a limited ability to represent the underlying heterogeneous tissue properties of varying sizes, locations, and distributions. In this paper, we present a novel framework that, going beyond a uniform low-resolution approach, is able to obtain a higher resolution estimation of tissue properties represented by spatially non-uniform resolution. This is achieved by two central elements: 1) a multi-scale coarse-to-fine optimization that facilitates higher resolution optimization using the lower resolution solution and 2) a spatially adaptive decision criterion that retains lower resolution in homogeneous tissue regions and allows higher resolution in heterogeneous tissue regions. The presented framework is evaluated in estimating the local tissue excitability properties of a cardiac EP model on both synthetic and real data experiments. Its performance is compared with optimization using pre-defined segments. Results demonstrate the feasibility of the presented framework to estimate local parameters and to reveal heterogeneous tissue properties at a higher resolution without using a high number of unknowns.

Original languageEnglish (US)
Article number7911242
Pages (from-to)1966-1978
Number of pages13
JournalIEEE transactions on medical imaging
Volume36
Issue number9
DOIs
StatePublished - Sep 2017

Keywords

  • Gaussian process
  • Parameter estimation
  • cardiac electro-physiological model
  • multi-scale optimization

ASJC Scopus subject areas

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering

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