Spatial patterns of structural brain changes in type 2 diabetic patients and their longitudinal progression with intensive control of blood glucose

Guray Erus, Harsha Battapady, Tianhao Zhang, James Lovato, Michael E. Miller, Jeff D. Williamson, Lenore J. Launer, R. Nick Bryan, Christos Davatzikos

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Understanding the effect of diabetes as well as of alternative treatment strategies on cerebral structure is critical for the development of targeted interventions against accelerated neurodegeneration in type 2 diabetes. We investigated whether diabetes characteristics were associated with spatially specific patterns of brain changes and whether those patterns were affected by intensive versus standard glycemic treatment.

RESEARCH DESIGN AND METHODS: Using baseline MRIs of 488 participants with type 2 diabetes from the Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes (ACCORD-MIND) study, we applied a new voxel-based analysis methodology to identify spatially specific patterns of gray matter and white matter volume loss related to diabetes duration and HbA1c. The longitudinal analysis used 40-month follow-up data to evaluate differences in progression of volume loss between intensive and standard glycemic treatment arms.

RESULTS: Participants with longer diabetes duration had significantly lower gray matter volumes, primarily in certain regions in the frontal and temporal lobes. The longitudinal analysis of treatment effects revealed a heterogeneous pattern of decelerated loss of gray matter volume associated with intensive glycemic treatment. Intensive treatment decelerated volume loss, particularly in regions adjacent to those cross-sectionally associated with diabetes duration. No significant relationship between low versus high baseline HbA1c levels and brain changes was found. Finally, regions inwhich cognitive change was associatedwith longitudinal volume loss had only small overlap with regions related to diabetes duration and to treatment effects.

CONCLUSIONS: Applying advanced quantitative image pattern analysis methods on longitudinal MRI data of a large sample of patients with type 2 diabetes, we demonstrate that there are spatially specific patterns of brain changes that vary by diabetes characteristics and that the progression of gray matter volume loss is slowed by intensive glycemic treatment, particularly in regions adjacent to areas affected by diabetes.

Original languageEnglish (US)
Pages (from-to)97-104
Number of pages8
JournalDiabetes Care
Volume38
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

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Blood Glucose
Brain
Type 2 Diabetes Mellitus
Therapeutics
Frontal Lobe
Temporal Lobe
Gray Matter

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Spatial patterns of structural brain changes in type 2 diabetic patients and their longitudinal progression with intensive control of blood glucose. / Erus, Guray; Battapady, Harsha; Zhang, Tianhao; Lovato, James; Miller, Michael E.; Williamson, Jeff D.; Launer, Lenore J.; Bryan, R. Nick; Davatzikos, Christos.

In: Diabetes Care, Vol. 38, No. 1, 01.01.2015, p. 97-104.

Research output: Contribution to journalArticle

Erus, G, Battapady, H, Zhang, T, Lovato, J, Miller, ME, Williamson, JD, Launer, LJ, Bryan, RN & Davatzikos, C 2015, 'Spatial patterns of structural brain changes in type 2 diabetic patients and their longitudinal progression with intensive control of blood glucose', Diabetes Care, vol. 38, no. 1, pp. 97-104. https://doi.org/10.2337/dc14-1196
Erus, Guray ; Battapady, Harsha ; Zhang, Tianhao ; Lovato, James ; Miller, Michael E. ; Williamson, Jeff D. ; Launer, Lenore J. ; Bryan, R. Nick ; Davatzikos, Christos. / Spatial patterns of structural brain changes in type 2 diabetic patients and their longitudinal progression with intensive control of blood glucose. In: Diabetes Care. 2015 ; Vol. 38, No. 1. pp. 97-104.
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AU - Miller, Michael E.

AU - Williamson, Jeff D.

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